Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE(toxin) |
| Location | 1397778..1398337 | Replicon | chromosome |
| Accession | NZ_CP020034 | ||
| Organism | Vibrio parahaemolyticus strain 20130629002S01 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | Vp2S01_RS07465 | Protein ID | WP_031856368.1 |
| Coordinates | 1397778..1398056 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U2ZGZ5 |
| Locus tag | Vp2S01_RS07470 | Protein ID | WP_005497249.1 |
| Coordinates | 1398053..1398337 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Vp2S01_RS07415 | 1392836..1392946 | + | 111 | WP_079861117.1 | DUF3265 domain-containing protein | - |
| Vp2S01_RS07420 | 1392982..1393590 | + | 609 | WP_025796196.1 | pyridoxamine 5'-phosphate oxidase family protein | - |
| Vp2S01_RS07425 | 1394221..1394310 | + | 90 | WP_079878894.1 | DUF3265 domain-containing protein | - |
| Vp2S01_RS07430 | 1394337..1394768 | + | 432 | WP_031856582.1 | DUF2513 domain-containing protein | - |
| Vp2S01_RS07435 | 1394755..1394886 | + | 132 | WP_079882753.1 | DUF3265 domain-containing protein | - |
| Vp2S01_RS07440 | 1394924..1395523 | + | 600 | WP_031856598.1 | hypothetical protein | - |
| Vp2S01_RS07445 | 1395658..1396188 | + | 531 | WP_085576757.1 | hypothetical protein | - |
| Vp2S01_RS07455 | 1396815..1397171 | + | 357 | WP_017449618.1 | hypothetical protein | - |
| Vp2S01_RS07460 | 1397186..1397278 | + | 93 | WP_072600995.1 | DUF3265 domain-containing protein | - |
| Vp2S01_RS07465 | 1397778..1398056 | - | 279 | WP_031856368.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| Vp2S01_RS07470 | 1398053..1398337 | - | 285 | WP_005497249.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| Vp2S01_RS07475 | 1398548..1398973 | + | 426 | WP_031856367.1 | hypothetical protein | - |
| Vp2S01_RS07490 | 1399735..1400010 | + | 276 | WP_031856366.1 | antibiotic biosynthesis monooxygenase | - |
| Vp2S01_RS07500 | 1400172..1400801 | + | 630 | WP_031856365.1 | hypothetical protein | - |
| Vp2S01_RS07505 | 1400821..1400913 | + | 93 | WP_004748931.1 | DUF3265 domain-containing protein | - |
| Vp2S01_RS07510 | 1400945..1401250 | + | 306 | WP_021453216.1 | hypothetical protein | - |
| Vp2S01_RS07515 | 1401407..1401895 | + | 489 | WP_031856291.1 | DUF523 domain-containing protein | - |
| Vp2S01_RS07520 | 1401913..1402002 | + | 90 | Protein_1288 | DUF3265 domain-containing protein | - |
| Vp2S01_RS07525 | 1402103..1402345 | + | 243 | Protein_1289 | DUF4476 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 | 1313826..1768428 | 454602 | |
| - | flank | IS/Tn | - | - | 1402426..1403346 | 920 | |
| - | inside | Integron | - | - | 1304414..1428522 | 124108 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10915.56 Da Isoelectric Point: 4.4548
>T73825 WP_031856368.1 NZ_CP020034:c1398056-1397778 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAANKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPEAANKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T73825 NZ_CP020034:c1398056-1397778 [Vibrio parahaemolyticus]
ATGATTTTGTGGGAAGAAGAGTCCCTCAACGATCGCGAAAAGATCTTTGAGTTTCTCTACGACTTCAACCCCGAAGCTGC
TAACAAAACCGACGATATTATTGAAGCAAAAGTTGAGAACCTTTTAGAGCAACCTCATATGGGAGTCCAGCGTGACGGAA
TTAGAGGGCGATTGCTCATTATTCCTGAGATTTCGATGATTGTTTCCTACTGGGTTGAAGGTGATATCATTCGAGTTATG
CGTGTGCTACACCAAAAACAAAAATTCCCAACGGACTAA
ATGATTTTGTGGGAAGAAGAGTCCCTCAACGATCGCGAAAAGATCTTTGAGTTTCTCTACGACTTCAACCCCGAAGCTGC
TAACAAAACCGACGATATTATTGAAGCAAAAGTTGAGAACCTTTTAGAGCAACCTCATATGGGAGTCCAGCGTGACGGAA
TTAGAGGGCGATTGCTCATTATTCCTGAGATTTCGATGATTGTTTCCTACTGGGTTGAAGGTGATATCATTCGAGTTATG
CGTGTGCTACACCAAAAACAAAAATTCCCAACGGACTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10913.25 Da Isoelectric Point: 9.1865
>AT73825 WP_005497249.1 NZ_CP020034:c1398337-1398053 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL
Download Length: 285 bp
>AT73825 NZ_CP020034:c1398337-1398053 [Vibrio parahaemolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACGAAGCGACTAGCCCAACAAATGGCTGAAAGCCAAGGCAGAAC
ACTAAGTGATGCTTGTCGTGAACTGACTGAGCAACTAGCTGACCAACAGAGAAAGACTTTATCTCACGACGCATGGTTAA
CTGAACAAGTTAACTTAGCTTTTGAGAAGTTTGACTCAGGAAAAGCCACTTTTGTTGACCATGAGTCAGCTAAATCTCGT
ATGGCCGAGCGTAAAGCTAAAATCCGTAACCGAGGCAAATTATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACGAAGCGACTAGCCCAACAAATGGCTGAAAGCCAAGGCAGAAC
ACTAAGTGATGCTTGTCGTGAACTGACTGAGCAACTAGCTGACCAACAGAGAAAGACTTTATCTCACGACGCATGGTTAA
CTGAACAAGTTAACTTAGCTTTTGAGAAGTTTGACTCAGGAAAAGCCACTTTTGTTGACCATGAGTCAGCTAAATCTCGT
ATGGCCGAGCGTAAAGCTAAAATCCGTAACCGAGGCAAATTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|