Detailed information of TA system TA073823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1195250..1195779
• Replicon: chromosome
• Accession: NZ_CP020033
• Organism: Corynebacterium glutamicum strain TCCC11822

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: B5C28_RS05590
• Protein ID: WP_075348157.1
• Coordinates: 1195480..1195779 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1B4WJV4
• Locus tag: B5C28_RS05585
• Protein ID: WP_060564305.1
• Coordinates: 1195250..1195483 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B5C28_RS05565 (B5C28_05645)	1191295..1192518	-	1224	WP_004568082.1	alpha/beta hydrolase family protein	-
B5C28_RS05570 (B5C28_05650)	1192714..1193799	+	1086	WP_004568081.1	redox-regulated ATPase YchF	-
B5C28_RS05575 (B5C28_05655)	1193964..1194209	+	246	WP_060564304.1	hypothetical protein	-
B5C28_RS05580 (B5C28_05660)	1194543..1194983	+	441	WP_038583357.1	YtoQ family protein	-
B5C28_RS05585 (B5C28_05665)	1195250..1195483	+	234	WP_060564305.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
B5C28_RS05590 (B5C28_05670)	1195480..1195779	+	300	WP_075348157.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B5C28_RS05595 (B5C28_05675)	1195716..1196084	+	369	WP_060564306.1	helix-turn-helix domain-containing protein	-
B5C28_RS05600 (B5C28_05680)	1196302..1196859	-	558	WP_060564307.1	DUF6434 domain-containing protein	-
B5C28_RS05605 (B5C28_05685)	1196941..1197453	-	513	WP_146144404.1	hypothetical protein	-
B5C28_RS05610 (B5C28_05690)	1197709..1198131	+	423	WP_231135427.1	NUDIX domain-containing protein	-
B5C28_RS05615 (B5C28_05695)	1198295..1198678	+	384	WP_060564310.1	class I SAM-dependent methyltransferase	-
B5C28_RS05620 (B5C28_05700)	1198828..1199853	-	1026	WP_060564311.1	hypothetical protein	-
B5C28_RS05625 (B5C28_05705)	1199858..1200436	-	579	WP_060564312.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1194543..1205074	10531

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-74)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11529.07 Da
• Isoelectric Point: 10.6281

>T73823 WP_075348157.1 NZ_CP020033:1195480-1195779 [Corynebacterium glutamicum]
VSRYLLTPAAQHDLSLIWDFTESRWGISQAKKYIREIQSAVEYVAQDANRGRSREEIRLGYKSTAVGSHVIFYVQRTSHW
KAMKQPVWRPTSARQFVTS

Nucleotide

• Length: 300 bp

>T73823 NZ_CP020033:1195480-1195779 [Corynebacterium glutamicum]
GTGAGCAGGTACCTTCTTACACCGGCTGCACAGCATGATCTCTCCTTGATTTGGGATTTCACCGAGAGTCGTTGGGGTAT
AAGCCAAGCAAAGAAGTATATCCGTGAGATTCAATCAGCAGTGGAATATGTGGCACAAGATGCGAACCGTGGCCGTAGTC
GTGAGGAAATTCGCTTAGGTTATAAAAGCACTGCGGTAGGCAGCCATGTCATATTTTATGTCCAGCGCACGAGCCATTGG
AAGGCAATGAAACAGCCTGTCTGGAGACCGACATCGGCCAGGCAGTTCGTGACCTCATAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8475.39 Da
• Isoelectric Point: 4.1948

>AT73823 WP_060564305.1 NZ_CP020033:1195250-1195483 [Corynebacterium glutamicum]
MAMNTSISLDDHFASFLSEQVESGRYQTASEVIRAGLRLLEEREARLTALRAALVNGEMSGEAEEFDFDAFIASKSS

Nucleotide

• Length: 234 bp

>AT73823 NZ_CP020033:1195250-1195483 [Corynebacterium glutamicum]
ATGGCCATGAATACTTCCATCAGTCTTGATGATCATTTCGCTTCGTTCCTCAGTGAGCAGGTTGAATCCGGTCGGTACCA
GACAGCGAGTGAGGTCATCCGTGCAGGTCTGCGCTTGTTGGAGGAGCGGGAAGCTCGTCTAACTGCTTTACGTGCGGCGC
TTGTAAATGGAGAGATGAGTGGTGAGGCAGAAGAATTTGATTTTGATGCCTTTATCGCATCGAAAAGCTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4WJV4