Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1609945..1610557 Replicon chromosome
Accession NZ_CP020027
Organism Streptococcus pyogenes strain STAB090229

Toxin (Protein)


Gene name parE Uniprot ID Q1JEY4
Locus tag B4W66_RS08320 Protein ID WP_020905490.1
Coordinates 1610222..1610557 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag B4W66_RS08315 Protein ID WP_002988079.1
Coordinates 1609945..1610232 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4W66_RS08290 1605127..1606110 - 984 WP_020905487.1 tagatose-bisphosphate aldolase -
B4W66_RS08295 1606114..1607043 - 930 WP_076639463.1 tagatose-6-phosphate kinase -
B4W66_RS08300 1607089..1607604 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
B4W66_RS08305 1607639..1608067 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
B4W66_RS08310 1608511..1609284 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
B4W66_RS08315 1609945..1610232 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
B4W66_RS08320 1610222..1610557 + 336 WP_020905490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B4W66_RS08325 1610709..1610891 + 183 WP_020905491.1 DNA integration/recombination/inversion protein -
B4W66_RS08335 1611323..1611642 + 320 Protein_1552 tyrosine-type recombinase/integrase -
B4W66_RS08340 1611810..1612202 - 393 WP_002982716.1 30S ribosomal protein S9 -
B4W66_RS08345 1612223..1612669 - 447 WP_002982710.1 50S ribosomal protein L13 -
B4W66_RS08350 1612887..1613093 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
B4W66_RS08355 1613090..1613788 - 699 WP_161237464.1 hypothetical protein -
B4W66_RS08360 1613924..1614784 - 861 WP_002982687.1 DegV family protein -
B4W66_RS08365 1614881..1615399 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13147.98 Da        Isoelectric Point: 4.9405

>T73820 WP_020905490.1 NZ_CP020027:1610222-1610557 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIILYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T73820 NZ_CP020027:1610222-1610557 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCTTTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT73820 WP_002988079.1 NZ_CP020027:1609945-1610232 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT73820 NZ_CP020027:1609945-1610232 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1JEY4

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References