Detailed information of TA system TA073792

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 612007..612836
• Replicon: chromosome
• Accession: NZ_CP020025
• Organism: Escherichia coli strain WB61

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: B1T56_RS03185
• Protein ID: WP_105178376.1
• Coordinates: 612468..612836 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: B1T56_RS03180
• Protein ID: WP_001285602.1
• Coordinates: 612007..612387 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B1T56_RS23720	609504..609712	+	209	Protein_566	DUF905 domain-containing protein	-
B1T56_RS23935	609813..610559	+	747	Protein_567	DUF932 domain-containing protein	-
B1T56_RS23940	610584..611069	+	486	WP_000214307.1	antirestriction protein	-
B1T56_RS23945	611085..611495	+	411	Protein_569	hypothetical protein	-
B1T56_RS23950	611514..611996	+	483	WP_164879005.1	hypothetical protein	-
B1T56_RS03180	612007..612387	+	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
B1T56_RS03185	612468..612836	+	369	WP_105178376.1	TA system toxin CbtA family protein	Toxin
B1T56_RS03190	612988..614253	-	1266	Protein_573	IS3 family transposase	-
B1T56_RS03195	614342..614662	+	321	Protein_574	hypothetical protein	-
B1T56_RS03200	614679..614876	+	198	WP_000839249.1	DUF957 domain-containing protein	-
B1T56_RS23955	614961..615107	+	147	WP_173678258.1	hypothetical protein	-
B1T56_RS03215	615647..616036	-	390	Protein_577	HNH endonuclease	-
B1T56_RS03220	616035..616286	+	252	Protein_578	HNH endonuclease	-
B1T56_RS03225	616294..617274	-	981	WP_105178378.1	sialate O-acetylesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimH	612007..627854	15847
	-	flank	IS/Tn	-	-	612988..613644	656

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13654.68 Da
• Isoelectric Point: 7.2432

>T73792 WP_105178376.1 NZ_CP020025:612468-612836 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLAKGM

Nucleotide

• Length: 369 bp

>T73792 NZ_CP020025:612468-612836 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGCCAAGGGAATGTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT73792 WP_001285602.1 NZ_CP020025:612007-612387 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT73792 NZ_CP020025:612007-612387 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG