Detailed information of TA system TA073777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 847199..847731
• Replicon: chromosome
• Accession: NZ_CP020020
• Organism: Staphylococcus aureus strain ATCC 6538

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q8VLW9
• Locus tag: B4602_RS04285
• Protein ID: WP_001103944.1
• Coordinates: 847411..847731 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: B4602_RS04280
• Protein ID: WP_001058492.1
• Coordinates: 847199..847408 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4602_RS04245	842716..843936	-	1221	WP_000264181.1	site-specific integrase	-
B4602_RS04250	844024..844752	-	729	WP_042727546.1	staphylococcal enterotoxin type K	-
B4602_RS04255	844776..845504	-	729	WP_001033317.1	staphylococcal enterotoxin type Q	-
B4602_RS04260	845679..846413	-	735	WP_000142630.1	helix-turn-helix domain-containing protein	-
B4602_RS04265	846563..846775	+	213	WP_001063624.1	helix-turn-helix transcriptional regulator	-
B4602_RS04270	846776..847048	+	273	WP_001138298.1	helix-turn-helix domain-containing protein	-
B4602_RS04275	847060..847206	+	147	WP_012990927.1	hypothetical protein	-
B4602_RS04280	847199..847408	+	210	WP_001058492.1	hypothetical protein	Antitoxin
B4602_RS04285	847411..847731	+	321	WP_001103944.1	DUF1474 family protein	Toxin
B4602_RS04290	847798..848667	+	870	WP_042727545.1	primase alpha helix C-terminal domain-containing protein	-
B4602_RS04295	848684..850141	+	1458	WP_042727544.1	virulence-associated E family protein	-
B4602_RS04300	850443..850805	+	363	WP_042727543.1	hypothetical protein	-
B4602_RS04305	850807..851091	+	285	WP_042727542.1	hypothetical protein	-
B4602_RS04310	851088..851729	+	642	WP_042727541.1	pathogenicity island protein	-
B4602_RS04315	852303..852644	+	342	WP_042727540.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq	824600..856992	32392

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12636.31 Da
• Isoelectric Point: 4.8519

>T73777 WP_001103944.1 NZ_CP020020:847411-847731 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKKLKITE

Nucleotide

• Length: 321 bp

>T73777 NZ_CP020020:847411-847731 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTTTATTTAAAAGAGTTCGATGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT73777 WP_001058492.1 NZ_CP020020:847199-847408 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT73777 NZ_CP020020:847199-847408 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q8VLW9

Antitoxin

• AlphaFold DB: X5IA75