Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 829915..830392 Replicon chromosome
Accession NZ_CP020020
Organism Staphylococcus aureus strain ATCC 6538

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag B4602_RS04130 Protein ID WP_000052076.1
Coordinates 829915..830103 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag B4602_RS04135 Protein ID WP_001059690.1
Coordinates 830132..830392 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4602_RS04100 825957..826427 + 471 WP_000824472.1 hypothetical protein -
B4602_RS04105 826768..827454 + 687 WP_001548082.1 thermonuclease family protein -
B4602_RS04110 827811..828011 + 201 WP_001059082.1 cold-shock protein -
B4602_RS04115 828506..828724 - 219 WP_000005884.1 hypothetical protein -
B4602_RS04120 828786..829070 - 285 WP_001004394.1 hypothetical protein -
B4602_RS04125 829158..829727 - 570 WP_001106653.1 hypothetical protein -
B4602_RS04130 829915..830103 - 189 WP_000052076.1 hypothetical protein Toxin
B4602_RS04135 830132..830392 - 261 WP_001059690.1 hypothetical protein Antitoxin
B4602_RS04140 830733..830936 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
B4602_RS04145 830933..831169 - 237 WP_000368687.1 hypothetical protein -
B4602_RS04150 831394..831975 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
B4602_RS04155 832048..832665 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
B4602_RS04160 832820..833314 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
B4602_RS04165 833713..834135 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
B4602_RS04170 834283..834999 + 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 824600..856992 32392


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T73776 WP_000052076.1 NZ_CP020020:c830103-829915 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T73776 NZ_CP020020:c830103-829915 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT73776 WP_001059690.1 NZ_CP020020:c830392-830132 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT73776 NZ_CP020020:c830392-830132 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References