Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 873116..873592 Replicon chromosome
Accession NZ_CP020019
Organism Staphylococcus aureus strain 08S00974

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag B4603_RS04350 Protein ID WP_000052076.1
Coordinates 873116..873304 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag B4603_RS04355 Protein ID WP_001059690.1
Coordinates 873332..873592 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4603_RS04320 869145..869627 + 483 WP_000824489.1 hypothetical protein -
B4603_RS04325 869968..870654 + 687 WP_001574556.1 thermonuclease family protein -
B4603_RS04330 871011..871211 + 201 WP_001059082.1 cold-shock protein -
B4603_RS04335 871708..871926 - 219 WP_000005881.1 hypothetical protein -
B4603_RS04340 871987..872271 - 285 WP_001004403.1 hypothetical protein -
B4603_RS04345 872359..872928 - 570 WP_001106655.1 hypothetical protein -
B4603_RS04350 873116..873304 - 189 WP_000052076.1 hypothetical protein Toxin
B4603_RS04355 873332..873592 - 261 WP_001059690.1 hypothetical protein Antitoxin
B4603_RS04360 873934..874137 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
B4603_RS04365 874134..874370 - 237 WP_000368687.1 hypothetical protein -
B4603_RS04370 874595..875176 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
B4603_RS04375 875249..875866 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
B4603_RS04380 876015..876509 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
B4603_RS04385 876908..877330 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
B4603_RS04390 877478..878194 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T73765 WP_000052076.1 NZ_CP020019:c873304-873116 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T73765 NZ_CP020019:c873304-873116 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT73765 WP_001059690.1 NZ_CP020019:c873592-873332 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT73765 NZ_CP020019:c873592-873332 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References