Detailed information of TA system TA073764

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1842003..1842502
• Replicon: chromosome
• Accession: NZ_CP020017
• Organism: Tetragenococcus halophilus strain KUD23

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B2J85_RS08895
• Protein ID: WP_094243889.1
• Coordinates: 1842003..1842272 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A091CDY2
• Locus tag: B2J85_RS08900
• Protein ID: WP_014123804.1
• Coordinates: 1842269..1842502 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B2J85_RS08865	1837520..1837990	+	471	WP_061841111.1	hypothetical protein	-
B2J85_RS08870	1838059..1838886	-	828	WP_094243886.1	hypothetical protein	-
B2J85_RS08875	1839159..1840109	-	951	WP_094243887.1	acetamidase/formamidase family protein	-
B2J85_RS08880	1840240..1840431	+	192	WP_014123808.1	type II toxin-antitoxin system HicA family toxin	-
B2J85_RS08885	1840470..1840871	+	402	WP_014123807.1	type II toxin-antitoxin system HicB family antitoxin	-
B2J85_RS08890	1841292..1841570	-	279	WP_094243888.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
B2J85_RS08895	1842003..1842272	-	270	WP_094243889.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B2J85_RS08900	1842269..1842502	-	234	WP_014123804.1	hypothetical protein	Antitoxin
B2J85_RS08905	1842714..1844003	-	1290	WP_094244185.1	group II intron reverse transcriptase/maturase	-
B2J85_RS08910	1844585..1844815	-	231	Protein_1746	DUF302 domain-containing protein	-
B2J85_RS08915	1845042..1845668	-	627	WP_068710712.1	methyltransferase domain-containing protein	-
B2J85_RS12790	1845908..1846165	-	258	Protein_1748	DUF302 domain-containing protein	-
B2J85_RS08925	1846194..1846457	-	264	WP_094243891.1	SHOCT domain-containing protein	-
B2J85_RS08930	1846469..1846651	-	183	WP_010620812.1	SHOCT domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10452.22 Da
• Isoelectric Point: 10.7221

>T73764 WP_094243889.1 NZ_CP020017:c1842272-1842003 [Tetragenococcus halophilus]
MTFHVETTPRFDKQLKKLDKFAANTILKWLDKNIEGSNNPRLMGKPLVGNHSGKWRYRIGSYRVITKVDDEKLIILALEV
GHRKDIYRK

Nucleotide

• Length: 270 bp

>T73764 NZ_CP020017:c1842272-1842003 [Tetragenococcus halophilus]
ATGACTTTTCATGTAGAGACAACTCCTAGGTTCGATAAGCAATTAAAAAAATTAGACAAATTTGCTGCAAACACTATACT
TAAGTGGCTTGATAAAAATATTGAAGGAAGCAATAATCCAAGATTGATGGGTAAACCGCTCGTTGGAAATCACTCTGGGA
AATGGCGCTATCGAATAGGAAGTTATCGTGTGATTACCAAGGTTGACGACGAAAAATTAATTATTTTAGCCTTAGAAGTG
GGACACAGGAAAGATATTTATAGAAAATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8599.41 Da
• Isoelectric Point: 3.8597

>AT73764 WP_014123804.1 NZ_CP020017:c1842502-1842269 [Tetragenococcus halophilus]
MATITVRVTDEEKDFLDNMAKFEGKSLSELLKTTTLSSLEDAYDAQIGDAAYDEYLKNPQSRPLSESLEEYGLGESE

Nucleotide

• Length: 234 bp

>AT73764 NZ_CP020017:c1842502-1842269 [Tetragenococcus halophilus]
ATGGCTACTATTACTGTACGCGTTACTGATGAAGAAAAAGATTTTTTAGATAATATGGCAAAGTTTGAGGGAAAGAGTTT
GTCTGAACTATTAAAGACTACAACGCTGTCATCTTTAGAAGACGCCTATGATGCACAAATTGGGGATGCAGCTTATGATG
AGTATTTGAAAAATCCGCAATCCCGTCCTCTGTCAGAATCATTAGAGGAATACGGCTTAGGAGAGAGCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A091CDY2