Detailed information of TA system TA073762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1715506..1716005
• Replicon: chromosome
• Accession: NZ_CP020017
• Organism: Tetragenococcus halophilus strain KUD23

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B2J85_RS08220
• Protein ID: WP_094243812.1
• Coordinates: 1715506..1715775 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: B2J85_RS08225
• Protein ID: WP_094243813.1
• Coordinates: 1715772..1716005 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B2J85_RS08190	1711303..1711662	+	360	WP_094244179.1	hotdog fold thioesterase	-
B2J85_RS08195	1711929..1712183	-	255	WP_028790182.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
B2J85_RS08200	1712395..1713300	+	906	WP_094243809.1	ribokinase	-
B2J85_RS08205	1713324..1713476	+	153	Protein_1607	D-ribose pyranase	-
B2J85_RS08210	1713586..1714137	-	552	WP_094243810.1	GNAT family N-acetyltransferase	-
B2J85_RS12780	1714255..1714359	+	105	WP_157728022.1	type I toxin-antitoxin system Fst family toxin	-
B2J85_RS08215	1714881..1715372	-	492	WP_094243811.1	HAD hydrolase-like protein	-
B2J85_RS08220	1715506..1715775	-	270	WP_094243812.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B2J85_RS08225	1715772..1716005	-	234	WP_094243813.1	toxin-antitoxin system, antitoxin component	Antitoxin
B2J85_RS08230	1716184..1717410	-	1227	WP_094243814.1	MFS transporter	-
B2J85_RS12785	1717795..1717896	-	102	WP_157728051.1	IS3 family transposase	-
B2J85_RS08235	1717994..1718194	-	201	WP_157728024.1	DDE-type integrase/transposase/recombinase	-
B2J85_RS08240	1718225..1718476	-	252	WP_094243816.1	IS3 family transposase	-
B2J85_RS08245	1718608..1718829	-	222	WP_094243817.1	transposase	-
B2J85_RS08250	1719010..1720974	-	1965	WP_094243818.1	BglG family transcription antiterminator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10556.32 Da
• Isoelectric Point: 10.7843

>T73762 WP_094243812.1 NZ_CP020017:c1715775-1715506 [Tetragenococcus halophilus]
MTFHVETTRRFDKQLKKLDNFTAKTILKWLDKNIEGVNNPRTFGKPLVGNHSGKWRYRIGDYRVITKIDDKKLIILALEV
GHRKDIYKN

Nucleotide

• Length: 270 bp

>T73762 NZ_CP020017:c1715775-1715506 [Tetragenococcus halophilus]
ATGACTTTTCATGTGGAAACAACTCGTAGATTTGATAAGCAATTAAAAAAATTAGATAACTTTACTGCAAAGACTATACT
TAAGTGGCTTGATAAAAATATTGAAGGAGTTAATAACCCAAGAACTTTTGGTAAACCTTTAGTCGGAAATCATTCCGGAA
AATGGCGCTATCGAATCGGGGATTATCGTGTAATCACCAAAATAGACGATAAGAAATTGATTATTTTAGCTTTAGAAGTA
GGACATAGAAAAGATATTTATAAAAATTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8671.48 Da
• Isoelectric Point: 3.8704

>AT73762 WP_094243813.1 NZ_CP020017:c1716005-1715772 [Tetragenococcus halophilus]
MATITVRVTDEEKNFLDNMAKFEGKSLSELLKTTTLSSLEDAYDAQIGDTAYEEYLRDPQSRPLSESLEEYGLGESE

Nucleotide

• Length: 234 bp

>AT73762 NZ_CP020017:c1716005-1715772 [Tetragenococcus halophilus]
ATGGCTACTATTACTGTTCGTGTTACGGATGAAGAAAAAAATTTTTTAGATAATATGGCAAAGTTTGAGGGAAAAAGTTT
GTCTGAATTACTGAAAACCACGACGTTATCCTCTTTAGAAGACGCTTATGATGCACAAATTGGAGATACAGCCTATGAGG
AATACTTAAGGGATCCGCAATCTCGTCCTTTATCAGAATCACTAGAGGAGTATGGATTAGGAGAAAGTGAATGA