73761

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1643967..1644460 Replicon chromosome
Accession NZ_CP020017
Organism Tetragenococcus halophilus strain KUD23

Toxin (Protein)


Gene name relE Uniprot ID A0A2H6C3W3
Locus tag B2J85_RS07895 Protein ID WP_014123900.1
Coordinates 1643967..1644233 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2H6CKH8
Locus tag B2J85_RS07900 Protein ID WP_014123899.1
Coordinates 1644230..1644460 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2J85_RS07865 1640091..1640375 - 285 WP_014123908.1 type II toxin-antitoxin system YafQ family toxin -
B2J85_RS07870 1640365..1640610 - 246 WP_014123907.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
B2J85_RS07875 1640831..1641538 + 708 WP_014123906.1 DUF969 domain-containing protein -
B2J85_RS07880 1641522..1642442 + 921 WP_014123905.1 DUF979 domain-containing protein -
B2J85_RS07885 1642769..1643416 + 648 WP_014123904.1 pyroglutamyl-peptidase I -
B2J85_RS07890 1643572..1643754 + 183 WP_014123901.1 putative holin-like toxin -
B2J85_RS07895 1643967..1644233 - 267 WP_014123900.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B2J85_RS07900 1644230..1644460 - 231 WP_014123899.1 hypothetical protein Antitoxin
B2J85_RS07905 1644627..1644863 + 237 WP_014123898.1 hypothetical protein -
B2J85_RS07910 1645074..1646180 + 1107 WP_094243771.1 Ldh family oxidoreductase -
B2J85_RS07915 1646496..1647698 + 1203 WP_157728020.1 divalent metal cation transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10597.17 Da        Isoelectric Point: 10.0661

>T73761 WP_014123900.1 NZ_CP020017:c1644233-1643967 [Tetragenococcus halophilus]
MSYRLVFTSEIQKQFRKMDKYQATLITRWLYQHIDGIDDPRKFGKELTTNRSGQWRYRIGKYRVIVEIEDSQLVVLAVQV
GHEKNVYN

Download         Length: 267 bp

>T73761 NZ_CP020017:c1644233-1643967 [Tetragenococcus halophilus]
ATGAGCTACCGCTTAGTCTTCACTTCTGAAATACAAAAACAATTTAGAAAAATGGATAAATATCAGGCGACTTTAATTAC
TCGTTGGCTGTATCAGCATATTGATGGAATTGACGACCCTCGCAAATTTGGCAAAGAACTAACTACAAATCGGTCTGGTC
AATGGCGTTATAGAATTGGCAAATATCGTGTTATCGTTGAAATAGAAGATAGCCAATTGGTTGTACTAGCTGTTCAAGTT
GGTCATGAAAAAAATGTTTATAATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.94 Da        Isoelectric Point: 3.9487

>AT73761 WP_014123899.1 NZ_CP020017:c1644460-1644230 [Tetragenococcus halophilus]
MAMITVRVSDAEKEWLNYMADFYGISLSDLLKTYSMEQLEDEYDRQTAEIAYKHWLENGKQTVSMDEILSEFGGLE

Download         Length: 231 bp

>AT73761 NZ_CP020017:c1644460-1644230 [Tetragenococcus halophilus]
ATGGCTATGATTACAGTACGTGTAAGTGACGCGGAAAAAGAATGGTTGAATTATATGGCTGATTTCTACGGAATCTCTTT
GTCTGACCTTTTAAAAACCTATTCGATGGAACAATTAGAAGATGAATATGACCGCCAAACAGCTGAGATTGCATATAAAC
ATTGGCTCGAAAATGGTAAGCAAACAGTATCAATGGATGAAATTCTTTCTGAATTTGGAGGTTTAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H6C3W3

Antitoxin

Source ID Structure
AlphaFold DB A0A2H6CKH8

References