Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1322340..1322929 Replicon chromosome
Accession NZ_CP020014
Organism Haemophilus influenzae strain 11P6H

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag BVZ63_RS06575 Protein ID WP_005653200.1
Coordinates 1322340..1322588 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag BVZ63_RS06580 Protein ID WP_005653201.1
Coordinates 1322585..1322929 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVZ63_RS06550 1317820..1318452 + 633 WP_011272461.1 energy-coupling factor transporter transmembrane protein EcfT -
BVZ63_RS06555 1318454..1319080 + 627 WP_011272462.1 energy-coupling factor ABC transporter ATP-binding protein -
BVZ63_RS06560 1319187..1320377 - 1191 WP_005657030.1 aspartate/tyrosine/aromatic aminotransferase -
BVZ63_RS06565 1320517..1321605 - 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
BVZ63_RS06570 1321675..1322169 - 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
BVZ63_RS06575 1322340..1322588 + 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
BVZ63_RS06580 1322585..1322929 + 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BVZ63_RS06585 1322973..1325582 + 2610 WP_012054428.1 aminopeptidase N -
BVZ63_RS06590 1325654..1326268 - 615 WP_005657019.1 riboflavin synthase -
BVZ63_RS06595 1326312..1327706 + 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T73757 WP_005653200.1 NZ_CP020014:1322340-1322588 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T73757 NZ_CP020014:1322340-1322588 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT73757 WP_005653201.1 NZ_CP020014:1322585-1322929 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT73757 NZ_CP020014:1322585-1322929 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References