73756

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1036728..1037359 Replicon chromosome
Accession NZ_CP020014
Organism Haemophilus influenzae strain 11P6H

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag BVZ63_RS05165 Protein ID WP_005651560.1
Coordinates 1036728..1037126 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag BVZ63_RS05170 Protein ID WP_005648011.1
Coordinates 1037126..1037359 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVZ63_RS05145 1031912..1033030 + 1119 WP_005686201.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
BVZ63_RS05150 1033031..1034053 + 1023 WP_005651554.1 outer membrane-stress sensor serine endopeptidase DegS -
BVZ63_RS05155 1034127..1034942 - 816 WP_012054544.1 DNA-formamidopyrimidine glycosylase -
BVZ63_RS05160 1035173..1036708 - 1536 WP_012054543.1 L-2,4-diaminobutyrate decarboxylase -
BVZ63_RS05165 1036728..1037126 - 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
BVZ63_RS05170 1037126..1037359 - 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
BVZ63_RS05175 1037506..1038870 - 1365 WP_005664172.1 diaminobutyrate--2-oxoglutarate transaminase -
BVZ63_RS05180 1039217..1039387 - 171 WP_005613503.1 50S ribosomal protein L33 -
BVZ63_RS05185 1039399..1039635 - 237 WP_005542826.1 50S ribosomal protein L28 -
BVZ63_RS05190 1039848..1040513 - 666 WP_041174703.1 DNA repair protein RadC -
BVZ63_RS05195 1040677..1041879 + 1203 WP_105197740.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T73756 WP_005651560.1 NZ_CP020014:c1037126-1036728 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T73756 NZ_CP020014:c1037126-1036728 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT73756 WP_005648011.1 NZ_CP020014:c1037359-1037126 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT73756 NZ_CP020014:c1037359-1037126 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References