Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 1036728..1037359 | Replicon | chromosome |
Accession | NZ_CP020014 | ||
Organism | Haemophilus influenzae strain 11P6H |
Toxin (Protein)
Gene name | vapC | Uniprot ID | Q4QLW0 |
Locus tag | BVZ63_RS05165 | Protein ID | WP_005651560.1 |
Coordinates | 1036728..1037126 (-) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | Q4QLV9 |
Locus tag | BVZ63_RS05170 | Protein ID | WP_005648011.1 |
Coordinates | 1037126..1037359 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BVZ63_RS05145 | 1031912..1033030 | + | 1119 | WP_005686201.1 | bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD | - |
BVZ63_RS05150 | 1033031..1034053 | + | 1023 | WP_005651554.1 | outer membrane-stress sensor serine endopeptidase DegS | - |
BVZ63_RS05155 | 1034127..1034942 | - | 816 | WP_012054544.1 | DNA-formamidopyrimidine glycosylase | - |
BVZ63_RS05160 | 1035173..1036708 | - | 1536 | WP_012054543.1 | L-2,4-diaminobutyrate decarboxylase | - |
BVZ63_RS05165 | 1036728..1037126 | - | 399 | WP_005651560.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
BVZ63_RS05170 | 1037126..1037359 | - | 234 | WP_005648011.1 | type II toxin-antitoxin system antitoxin VapB2 | Antitoxin |
BVZ63_RS05175 | 1037506..1038870 | - | 1365 | WP_005664172.1 | diaminobutyrate--2-oxoglutarate transaminase | - |
BVZ63_RS05180 | 1039217..1039387 | - | 171 | WP_005613503.1 | 50S ribosomal protein L33 | - |
BVZ63_RS05185 | 1039399..1039635 | - | 237 | WP_005542826.1 | 50S ribosomal protein L28 | - |
BVZ63_RS05190 | 1039848..1040513 | - | 666 | WP_041174703.1 | DNA repair protein RadC | - |
BVZ63_RS05195 | 1040677..1041879 | + | 1203 | WP_105197740.1 | bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15115.46 Da Isoelectric Point: 8.0514
>T73756 WP_005651560.1 NZ_CP020014:c1037126-1036728 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV
Download Length: 399 bp
>T73756 NZ_CP020014:c1037126-1036728 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8880.98 Da Isoelectric Point: 4.4013
>AT73756 WP_005648011.1 NZ_CP020014:c1037359-1037126 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL
Download Length: 234 bp
>AT73756 NZ_CP020014:c1037359-1037126 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q4QLW0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A806DGS0 |