Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1007833..1008367 Replicon chromosome
Accession NZ_CP020014
Organism Haemophilus influenzae strain 11P6H

Toxin (Protein)


Gene name relE Uniprot ID A0A2R3GCN3
Locus tag BVZ63_RS05010 Protein ID WP_005651512.1
Coordinates 1007833..1008123 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A5Y2
Locus tag BVZ63_RS05015 Protein ID WP_005651514.1
Coordinates 1008113..1008367 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVZ63_RS04995 1005189..1005692 + 504 WP_005659127.1 hypothetical protein -
BVZ63_RS05000 1005692..1006726 + 1035 WP_005659128.1 DNA polymerase III subunit delta -
BVZ63_RS08945 1007236..1007373 - 138 WP_005659136.1 hypothetical protein -
BVZ63_RS05005 1007543..1007752 - 210 WP_074030365.1 hypothetical protein -
BVZ63_RS05010 1007833..1008123 - 291 WP_005651512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVZ63_RS05015 1008113..1008367 - 255 WP_005651514.1 stability protein StbD Antitoxin
BVZ63_RS05025 1008665..1008889 - 225 WP_005659141.1 hypothetical protein -
BVZ63_RS05030 1008889..1009197 - 309 WP_005659142.1 P2 family phage major capsid protein -
BVZ63_RS05035 1009227..1009766 - 540 WP_005659144.1 hypothetical protein -
BVZ63_RS05045 1010128..1012194 - 2067 WP_005686190.1 glycine--tRNA ligase subunit beta -
BVZ63_RS05050 1012532..1012897 - 366 WP_005686191.1 endonuclease domain-containing protein -
BVZ63_RS05055 1012927..1013187 - 261 WP_005663579.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11482.41 Da        Isoelectric Point: 10.6484

>T73755 WP_005651512.1 NZ_CP020014:c1008123-1007833 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T73755 NZ_CP020014:c1008123-1007833 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACTATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9419.78 Da        Isoelectric Point: 4.0737

>AT73755 WP_005651514.1 NZ_CP020014:c1008367-1008113 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp

>AT73755 NZ_CP020014:c1008367-1008113 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCCGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAGCTCGGCAGAATGGCAAATGAACGGCTAGCCACCCTAGAACCAGTAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3GCN3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYX4

References