Detailed information of TA system TA073752

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 714101..714572
• Replicon: chromosome
• Accession: NZ_CP020014
• Organism: Haemophilus influenzae strain 11P6H

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: BVZ63_RS03545
• Protein ID: WP_005654546.1
• Coordinates: 714390..714572 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: BVZ63_RS03540
• Protein ID: WP_005650837.1
• Coordinates: 714101..714397 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BVZ63_RS03515	709308..710066	-	759	WP_012054646.1	DUF3800 domain-containing protein	-
BVZ63_RS03520	710078..710884	-	807	WP_105197694.1	shikimate dehydrogenase	-
BVZ63_RS03525	710888..711439	-	552	WP_105197696.1	Sua5/YciO/YrdC/YwlC family protein	-
BVZ63_RS03530	711455..711991	-	537	WP_105197698.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
BVZ63_RS03535	712001..713917	-	1917	WP_105197700.1	ABC transporter ATP-binding protein	-
BVZ63_RS03540	714101..714397	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
BVZ63_RS03545	714390..714572	-	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
BVZ63_RS03550	714842..717808	-	2967	WP_105197702.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
BVZ63_RS03555	718178..718342	+	165	WP_012054638.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T73752 WP_005654546.1 NZ_CP020014:c714572-714390 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T73752 NZ_CP020014:c714572-714390 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAATATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT73752 WP_005650837.1 NZ_CP020014:c714397-714101 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT73752 NZ_CP020014:c714397-714101 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAACAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9