73752

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 714101..714572 Replicon chromosome
Accession NZ_CP020014
Organism Haemophilus influenzae strain 11P6H

Toxin (Protein)


Gene name toxT Uniprot ID A0A806DTA9
Locus tag BVZ63_RS03545 Protein ID WP_005654546.1
Coordinates 714390..714572 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag BVZ63_RS03540 Protein ID WP_005650837.1
Coordinates 714101..714397 (-) Length 99 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVZ63_RS03515 709308..710066 - 759 WP_012054646.1 DUF3800 domain-containing protein -
BVZ63_RS03520 710078..710884 - 807 WP_105197694.1 shikimate dehydrogenase -
BVZ63_RS03525 710888..711439 - 552 WP_105197696.1 Sua5/YciO/YrdC/YwlC family protein -
BVZ63_RS03530 711455..711991 - 537 WP_105197698.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
BVZ63_RS03535 712001..713917 - 1917 WP_105197700.1 ABC transporter ATP-binding protein -
BVZ63_RS03540 714101..714397 - 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
BVZ63_RS03545 714390..714572 - 183 WP_005654546.1 shikimate 5-dehydrogenase Toxin
BVZ63_RS03550 714842..717808 - 2967 WP_105197702.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
BVZ63_RS03555 718178..718342 + 165 WP_012054638.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(34-89)


Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 7318.33 Da        Isoelectric Point: 6.3057

>T73752 WP_005654546.1 NZ_CP020014:c714572-714390 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Download         Length: 183 bp

>T73752 NZ_CP020014:c714572-714390 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAATATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT73752 WP_005650837.1 NZ_CP020014:c714397-714101 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp

>AT73752 NZ_CP020014:c714397-714101 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAACAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A806DTA9


Antitoxin

Source ID Structure

References