73751

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 518568..518905 Replicon chromosome
Accession NZ_CP020014
Organism Haemophilus influenzae strain 11P6H

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag BVZ63_RS02510 Protein ID WP_005686917.1
Coordinates 518568..518705 (-) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag BVZ63_RS02515 Protein ID WP_005649350.1
Coordinates 518714..518905 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVZ63_RS02490 513759..515429 - 1671 WP_005686908.1 fructose-specific PTS transporter subunit EIIC -
BVZ63_RS02495 515431..516372 - 942 WP_005686910.1 1-phosphofructokinase -
BVZ63_RS02500 516374..517873 - 1500 WP_005686912.1 fused PTS fructose transporter subunit IIA/HPr protein -
BVZ63_RS02505 517945..518475 - 531 WP_005686915.1 hypothetical protein -
BVZ63_RS02510 518568..518705 - 138 WP_005686917.1 hypothetical protein Toxin
BVZ63_RS02515 518714..518905 - 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
BVZ63_RS02520 518977..520275 - 1299 WP_032821624.1 hemolysin family protein -
BVZ63_RS02525 520326..520850 - 525 WP_005686921.1 DUF1523 family protein -
BVZ63_RS02530 520877..521659 - 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
BVZ63_RS02535 521714..522697 - 984 WP_005686925.1 DNA polymerase III subunit delta' -
BVZ63_RS02540 522694..523326 - 633 WP_005686927.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T73751 WP_005686917.1 NZ_CP020014:c518705-518568 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T73751 NZ_CP020014:c518705-518568 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT73751 WP_005649350.1 NZ_CP020014:c518905-518714 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT73751 NZ_CP020014:c518905-518714 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References