Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 392279..392916 Replicon chromosome
Accession NZ_CP020014
Organism Haemophilus influenzae strain 11P6H

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag BVZ63_RS01860 Protein ID WP_005659980.1
Coordinates 392512..392916 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag BVZ63_RS01855 Protein ID WP_005656316.1
Coordinates 392279..392515 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVZ63_RS01830 387507..388247 - 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -
BVZ63_RS01835 388407..388883 - 477 WP_005686755.1 dihydroneopterin triphosphate diphosphatase -
BVZ63_RS01840 388905..390671 - 1767 WP_054456884.1 aspartate--tRNA ligase -
BVZ63_RS01845 390890..391408 + 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
BVZ63_RS01850 391461..392186 + 726 WP_005669008.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
BVZ63_RS01855 392279..392515 + 237 WP_005656316.1 antitoxin Antitoxin
BVZ63_RS01860 392512..392916 + 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
BVZ63_RS01865 392983..393390 + 408 WP_005654069.1 lactoylglutathione lyase -
BVZ63_RS01870 393464..394153 + 690 WP_005686760.1 ribonuclease T -
BVZ63_RS01875 394469..395821 + 1353 WP_005686762.1 Na+/H+ antiporter family protein -
BVZ63_RS01880 395853..396437 + 585 WP_005686764.1 primosomal replication protein -
BVZ63_RS01890 396789..397355 - 567 WP_005544066.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T73750 WP_005659980.1 NZ_CP020014:392512-392916 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T73750 NZ_CP020014:392512-392916 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT73750 WP_005656316.1 NZ_CP020014:392279-392515 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT73750 NZ_CP020014:392279-392515 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References