73742

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 607091..607428 Replicon chromosome
Accession NZ_CP020013
Organism Haemophilus influenzae strain 6P32H1

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag BV140_RS03070 Protein ID WP_005686917.1
Coordinates 607091..607228 (-) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag BV140_RS03075 Protein ID WP_005649350.1
Coordinates 607237..607428 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV140_RS03050 602282..603952 - 1671 WP_005686908.1 fructose-specific PTS transporter subunit EIIC -
BV140_RS03055 603954..604895 - 942 WP_005686910.1 1-phosphofructokinase -
BV140_RS03060 604897..606396 - 1500 WP_005686912.1 fused PTS fructose transporter subunit IIA/HPr protein -
BV140_RS03065 606468..606998 - 531 WP_005686915.1 hypothetical protein -
BV140_RS03070 607091..607228 - 138 WP_005686917.1 hypothetical protein Toxin
BV140_RS03075 607237..607428 - 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
BV140_RS03080 607500..608798 - 1299 WP_032821624.1 hemolysin family protein -
BV140_RS03085 608849..609373 - 525 WP_005686921.1 DUF1523 family protein -
BV140_RS03090 609400..610182 - 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
BV140_RS03095 610237..611220 - 984 WP_005686925.1 DNA polymerase III subunit delta' -
BV140_RS03100 611217..611849 - 633 WP_005686927.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T73742 WP_005686917.1 NZ_CP020013:c607228-607091 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T73742 NZ_CP020013:c607228-607091 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT73742 WP_005649350.1 NZ_CP020013:c607428-607237 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT73742 NZ_CP020013:c607428-607237 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References