Detailed information of TA system TA073739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1409543..1410132
• Replicon: chromosome
• Accession: NZ_CP020012
• Organism: Haemophilus influenzae strain 6P24H2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q709A1
• Locus tag: BV139_RS07125
• Protein ID: WP_005686594.1
• Coordinates: 1409543..1409791 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q9R3K0
• Locus tag: BV139_RS07130
• Protein ID: WP_005686595.1
• Coordinates: 1409788..1410132 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV139_RS07100	1405025..1405657	+	633	WP_005686586.1	energy-coupling factor transporter transmembrane protein EcfT	-
BV139_RS07105	1405659..1406285	+	627	WP_005686589.1	energy-coupling factor ABC transporter ATP-binding protein	-
BV139_RS07110	1406390..1407580	-	1191	WP_005686591.1	aspartate/tyrosine/aromatic aminotransferase	-
BV139_RS07115	1407720..1408808	-	1089	WP_005686592.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
BV139_RS07120	1408878..1409372	-	495	WP_005686593.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
BV139_RS07125	1409543..1409791	+	249	WP_005686594.1	type II toxin-antitoxin system HicA family toxin	Toxin
BV139_RS07130	1409788..1410132	+	345	WP_005686595.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BV139_RS07135	1410524..1413133	+	2610	WP_005686596.1	aminopeptidase N	-
BV139_RS07140	1413205..1413819	-	615	WP_005657019.1	riboflavin synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-81)

Antitoxin

• Uncharacterised protein family HicB (54-102)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9396.93 Da
• Isoelectric Point: 10.7140

>T73739 WP_005686594.1 NZ_CP020012:1409543-1409791 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELASLLAQQGYEKREMAGSRVRFYNRTLKHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Nucleotide

• Length: 249 bp

>T73739 NZ_CP020012:1409543-1409791 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGCTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCAAGCACACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 13123.03 Da
• Isoelectric Point: 5.0042

>AT73739 WP_005686595.1 NZ_CP020012:1409788-1410132 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFHQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIKEKIFREKPSLR

Nucleotide

• Length: 345 bp

>AT73739 NZ_CP020012:1409788-1410132 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTATTTGGCAAACTTGC
TTACATTCGTGATTTAGTAACTTACGAAGCAGAGTCATTATCTGAGTTAGAAAAAGAATTTCATCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCAACGATCATAGCTGGCGATCGTTCTCTTAATGCTTTTGTGACGGAAGCAATTAAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Structures

Toxin

• AlphaFold DB: Q709A1

Antitoxin

• AlphaFold DB: Q9R3K0