Detailed information of TA system TA073738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1124741..1125372
• Replicon: chromosome
• Accession: NZ_CP020012
• Organism: Haemophilus influenzae strain 6P24H2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q4QLW0
• Locus tag: BV139_RS05720
• Protein ID: WP_005651560.1
• Coordinates: 1124741..1125139 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BV139_RS05725
• Protein ID: WP_005686209.1
• Coordinates: 1125139..1125372 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV139_RS05700	1119934..1121052	+	1119	WP_005686201.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
BV139_RS05705	1121053..1122075	+	1023	WP_005655937.1	outer membrane-stress sensor serine endopeptidase DegS	-
BV139_RS05710	1122149..1122964	-	816	WP_005686204.1	DNA-formamidopyrimidine glycosylase	-
BV139_RS05715	1123186..1124721	-	1536	WP_005686206.1	L-2,4-diaminobutyrate decarboxylase	-
BV139_RS05720	1124741..1125139	-	399	WP_005651560.1	tRNA(fMet)-specific endonuclease VapC	Toxin
BV139_RS05725	1125139..1125372	-	234	WP_005686209.1	type II toxin-antitoxin system antitoxin VapB2	Antitoxin
BV139_RS05730	1125519..1126883	-	1365	WP_005686211.1	diaminobutyrate--2-oxoglutarate transaminase	-
BV139_RS05735	1127230..1127400	-	171	WP_005613503.1	50S ribosomal protein L33	-
BV139_RS05740	1127412..1127648	-	237	WP_005542826.1	50S ribosomal protein L28	-
BV139_RS05745	1127862..1128527	-	666	WP_032821549.1	DNA repair protein RadC	-
BV139_RS05750	1128691..1129893	+	1203	WP_005686217.1	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-56)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15115.46 Da
• Isoelectric Point: 8.0514

>T73738 WP_005651560.1 NZ_CP020012:c1125139-1124741 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Nucleotide

• Length: 399 bp

>T73738 NZ_CP020012:c1125139-1124741 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCGGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8911.01 Da
• Isoelectric Point: 4.4013

>AT73738 WP_005686209.1 NZ_CP020012:c1125372-1125139 [Haemophilus influenzae]
MIETSVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Nucleotide

• Length: 234 bp

>AT73738 NZ_CP020012:c1125372-1125139 [Haemophilus influenzae]
ATGATTGAAACCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Structures

Toxin

• AlphaFold DB: Q4QLW0