Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1095853..1096387 Replicon chromosome
Accession NZ_CP020012
Organism Haemophilus influenzae strain 6P24H2

Toxin (Protein)


Gene name relE Uniprot ID A0A2R3GCN3
Locus tag BV139_RS05565 Protein ID WP_005651512.1
Coordinates 1095853..1096143 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A5Y2
Locus tag BV139_RS05570 Protein ID WP_005651514.1
Coordinates 1096133..1096387 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV139_RS05550 1093209..1093712 + 504 WP_005659127.1 hypothetical protein -
BV139_RS05555 1093712..1094746 + 1035 WP_005659128.1 DNA polymerase III subunit delta -
BV139_RS09495 1095256..1095393 - 138 WP_005659136.1 hypothetical protein -
BV139_RS05560 1095563..1095772 - 210 WP_074030365.1 hypothetical protein -
BV139_RS05565 1095853..1096143 - 291 WP_005651512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV139_RS05570 1096133..1096387 - 255 WP_005651514.1 stability protein StbD Antitoxin
BV139_RS05580 1096685..1096909 - 225 WP_005659141.1 hypothetical protein -
BV139_RS05585 1096909..1097217 - 309 WP_005659142.1 P2 family phage major capsid protein -
BV139_RS05590 1097247..1097786 - 540 WP_005659144.1 hypothetical protein -
BV139_RS05600 1098148..1100214 - 2067 WP_005686190.1 glycine--tRNA ligase subunit beta -
BV139_RS05605 1100552..1100917 - 366 WP_005686191.1 endonuclease domain-containing protein -
BV139_RS05610 1100947..1101207 - 261 WP_005663579.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11482.41 Da        Isoelectric Point: 10.6484

>T73737 WP_005651512.1 NZ_CP020012:c1096143-1095853 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T73737 NZ_CP020012:c1096143-1095853 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACTATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9419.78 Da        Isoelectric Point: 4.0737

>AT73737 WP_005651514.1 NZ_CP020012:c1096387-1096133 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp

>AT73737 NZ_CP020012:c1096387-1096133 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCCGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAGCTCGGCAGAATGGCAAATGAACGGCTAGCCACCCTAGAACCAGTAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3GCN3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYX4

References