Detailed information of TA system TA073734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 802042..802513
• Replicon: chromosome
• Accession: NZ_CP020012
• Organism: Haemophilus influenzae strain 6P24H2

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: BV139_RS04100
• Protein ID: WP_005654546.1
• Coordinates: 802331..802513 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: BV139_RS04095
• Protein ID: WP_005650837.1
• Coordinates: 802042..802338 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV139_RS04070	797216..798007	-	792	WP_005688143.1	DUF3800 domain-containing protein	-
BV139_RS04075	798019..798825	-	807	WP_005688144.1	shikimate dehydrogenase	-
BV139_RS04080	798829..799380	-	552	WP_005688145.1	Sua5/YciO/YrdC/YwlC family protein	-
BV139_RS04085	799396..799932	-	537	WP_005688146.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
BV139_RS04090	799942..801858	-	1917	WP_005688147.1	ABC transporter ATP-binding protein	-
BV139_RS04095	802042..802338	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
BV139_RS04100	802331..802513	-	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
BV139_RS04105	802783..805900	-	3118	Protein_759	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T73734 WP_005654546.1 NZ_CP020012:c802513-802331 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T73734 NZ_CP020012:c802513-802331 [Haemophilus influenzae]
ATGTACGAAATTCTCTTTTACAGAGACCAAAATGACATTGAACCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACTGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT73734 WP_005650837.1 NZ_CP020012:c802338-802042 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT73734 NZ_CP020012:c802338-802042 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGTCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9