Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 436994..437631 Replicon chromosome
Accession NZ_CP020012
Organism Haemophilus influenzae strain 6P24H2

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag BV139_RS02120 Protein ID WP_005659980.1
Coordinates 437227..437631 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag BV139_RS02115 Protein ID WP_005656316.1
Coordinates 436994..437230 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV139_RS02090 432222..432962 - 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -
BV139_RS02095 433122..433598 - 477 WP_005686755.1 dihydroneopterin triphosphate diphosphatase -
BV139_RS02100 433620..435386 - 1767 WP_005686757.1 aspartate--tRNA ligase -
BV139_RS02105 435605..436123 + 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
BV139_RS02110 436176..436901 + 726 WP_005669008.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
BV139_RS02115 436994..437230 + 237 WP_005656316.1 antitoxin Antitoxin
BV139_RS02120 437227..437631 + 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
BV139_RS02125 437698..438105 + 408 WP_005654069.1 lactoylglutathione lyase -
BV139_RS02130 438179..438868 + 690 WP_005686760.1 ribonuclease T -
BV139_RS02135 439184..440536 + 1353 WP_005686762.1 Na+/H+ antiporter family protein -
BV139_RS02140 440568..441152 + 585 WP_005686764.1 primosomal replication protein -
BV139_RS02150 441504..442070 - 567 WP_005544066.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T73732 WP_005659980.1 NZ_CP020012:437227-437631 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T73732 NZ_CP020012:437227-437631 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT73732 WP_005656316.1 NZ_CP020012:436994-437230 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT73732 NZ_CP020012:436994-437230 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References