Detailed information of TA system TA073728

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 771322..771926
• Replicon: chromosome
• Accession: NZ_CP020011
• Organism: Haemophilus influenzae strain 67P56H1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BV134_RS03870
• Protein ID: WP_050823020.1
• Coordinates: 771618..771926 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BV134_RS03865
• Protein ID: WP_005664792.1
• Coordinates: 771322..771618 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV134_RS03850	767088..768473	+	1386	WP_014551098.1	L-seryl-tRNA(Sec) selenium transferase	-
BV134_RS03855	768470..770329	+	1860	WP_050823022.1	selenocysteine-specific translation elongation factor	-
BV134_RS03860	770348..771202	+	855	WP_050823021.1	DUF3298 domain-containing protein	-
BV134_RS03865	771322..771618	+	297	WP_005664792.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BV134_RS03870	771618..771926	+	309	WP_050823020.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
BV134_RS03875	771983..775183	-	3201	WP_105175965.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
BV134_RS03880	775513..776811	+	1299	WP_050823045.1	trigger factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (7-100)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-93)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11962.77 Da
• Isoelectric Point: 8.4515

>T73728 WP_050823020.1 NZ_CP020011:771618-771926 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNLLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGNLVLIYQYV
IRDEFDELKFSRLNTHSQTALK

Nucleotide

• Length: 309 bp

>T73728 NZ_CP020011:771618-771926 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATTTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCAATTTGGTACTGATTTACCAATACGTT
ATACGCGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11061.31 Da
• Isoelectric Point: 4.2087

>AT73728 WP_005664792.1 NZ_CP020011:771322-771618 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLEAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Nucleotide

• Length: 297 bp

>AT73728 NZ_CP020011:771322-771618 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGAAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA