Detailed information of TA system TA073726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 710414..710885
• Replicon: chromosome
• Accession: NZ_CP020011
• Organism: Haemophilus influenzae strain 67P56H1

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: BV134_RS03585
• Protein ID: WP_005654546.1
• Coordinates: 710703..710885 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: BV134_RS03580
• Protein ID: WP_005650837.1
• Coordinates: 710414..710710 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV134_RS03555	705602..706165	-	564	WP_042601571.1	DNA-3-methyladenine glycosylase I	-
BV134_RS03560	706379..707185	-	807	WP_050822741.1	shikimate dehydrogenase	-
BV134_RS03565	707189..707740	-	552	WP_050822744.1	Sua5/YciO/YrdC/YwlC family protein	-
BV134_RS03570	707756..708304	-	549	WP_050822746.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
BV134_RS03575	708314..710230	-	1917	WP_050822748.1	ABC transporter ATP-binding protein	-
BV134_RS03580	710414..710710	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
BV134_RS03585	710703..710885	-	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
BV134_RS03590	711155..714221	-	3067	Protein_655	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T73726 WP_005654546.1 NZ_CP020011:c710885-710703 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T73726 NZ_CP020011:c710885-710703 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT73726 WP_005650837.1 NZ_CP020011:c710710-710414 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT73726 NZ_CP020011:c710710-710414 [Haemophilus influenzae]
ATGAATAAAATTAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGTCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9