Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 560686..561323 Replicon chromosome
Accession NZ_CP020011
Organism Haemophilus influenzae strain 67P56H1

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag BV134_RS02780 Protein ID WP_005659980.1
Coordinates 560686..561090 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag BV134_RS02785 Protein ID WP_005656316.1
Coordinates 561087..561323 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV134_RS02750 556244..556810 + 567 WP_005544066.1 elongation factor P -
BV134_RS02760 557162..557749 - 588 WP_014550467.1 primosomal replication protein -
BV134_RS02765 557782..559134 - 1353 WP_005649062.1 Na+/H+ antiporter family protein -
BV134_RS02770 559449..560138 - 690 WP_005659978.1 ribonuclease T -
BV134_RS02775 560212..560619 - 408 WP_014550469.1 lactoylglutathione lyase -
BV134_RS02780 560686..561090 - 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
BV134_RS02785 561087..561323 - 237 WP_005656316.1 antitoxin Antitoxin
BV134_RS02790 561416..562141 - 726 WP_042611719.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
BV134_RS02795 562194..562712 - 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
BV134_RS02800 562931..564697 + 1767 WP_014550472.1 aspartate--tRNA ligase -
BV134_RS02805 564719..565195 + 477 WP_005686755.1 dihydroneopterin triphosphate diphosphatase -
BV134_RS02810 565355..566095 + 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T73725 WP_005659980.1 NZ_CP020011:c561090-560686 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T73725 NZ_CP020011:c561090-560686 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT73725 WP_005656316.1 NZ_CP020011:c561323-561087 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT73725 NZ_CP020011:c561323-561087 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References