Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 434297..434625 Replicon chromosome
Accession NZ_CP020011
Organism Haemophilus influenzae strain 67P56H1

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag BV134_RS02125 Protein ID WP_005686917.1
Coordinates 434488..434625 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID -
Locus tag BV134_RS02120 Protein ID WP_050822814.1
Coordinates 434297..434479 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV134_RS02095 429876..430508 + 633 WP_005686927.1 dTMP kinase -
BV134_RS02100 430505..431488 + 984 WP_014550403.1 DNA polymerase III subunit delta' -
BV134_RS02105 431543..432325 + 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
BV134_RS02110 432352..432876 + 525 WP_005686921.1 DUF1523 family protein -
BV134_RS02115 432927..434225 + 1299 WP_014550404.1 hemolysin family protein -
BV134_RS02120 434297..434479 + 183 WP_050822814.1 DUF5397 family protein Antitoxin
BV134_RS02125 434488..434625 + 138 WP_005686917.1 hypothetical protein Toxin
BV134_RS02130 434718..435248 + 531 WP_005686915.1 hypothetical protein -
BV134_RS02135 435320..436819 + 1500 WP_050822813.1 fused PTS fructose transporter subunit IIA/HPr protein -
BV134_RS02140 436821..437762 + 942 WP_014550407.1 1-phosphofructokinase -
BV134_RS02145 437764..439434 + 1671 WP_050822812.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-60)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T73724 WP_005686917.1 NZ_CP020011:434488-434625 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T73724 NZ_CP020011:434488-434625 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6730.71 Da        Isoelectric Point: 3.9930

>AT73724 WP_050822814.1 NZ_CP020011:434297-434479 [Haemophilus influenzae]
MELRQQIPTGCIKQFGVPYVVGEVAEFLLDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 183 bp

>AT73724 NZ_CP020011:434297-434479 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGTTGCGGAATT
TTTGCTAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTATCTCACCTAC
TTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure

References