Detailed information of TA system TA073718

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 710501..710972
• Replicon: chromosome
• Accession: NZ_CP020010
• Organism: Haemophilus influenzae strain 67P38H1

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: BV131_RS03595
• Protein ID: WP_005654546.1
• Coordinates: 710790..710972 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: BV131_RS03590
• Protein ID: WP_005650837.1
• Coordinates: 710501..710797 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV131_RS03565	705689..706252	-	564	WP_042601571.1	DNA-3-methyladenine glycosylase I	-
BV131_RS03570	706466..707272	-	807	WP_050822741.1	shikimate dehydrogenase	-
BV131_RS03575	707276..707827	-	552	WP_050822744.1	Sua5/YciO/YrdC/YwlC family protein	-
BV131_RS03580	707843..708391	-	549	WP_050822746.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
BV131_RS03585	708401..710317	-	1917	WP_050822748.1	ABC transporter ATP-binding protein	-
BV131_RS03590	710501..710797	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
BV131_RS03595	710790..710972	-	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
BV131_RS03600	711242..714300	-	3059	Protein_656	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T73718 WP_005654546.1 NZ_CP020010:c710972-710790 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T73718 NZ_CP020010:c710972-710790 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCGCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACAGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT73718 WP_005650837.1 NZ_CP020010:c710797-710501 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT73718 NZ_CP020010:c710797-710501 [Haemophilus influenzae]
ATGAATAAAATTAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGTCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9