Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 514134..514462 Replicon chromosome
Accession NZ_CP020010
Organism Haemophilus influenzae strain 67P38H1

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag BV131_RS02545 Protein ID WP_005686917.1
Coordinates 514134..514271 (-) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID -
Locus tag BV131_RS02550 Protein ID WP_050822814.1
Coordinates 514280..514462 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV131_RS02525 509325..510995 - 1671 WP_050822812.1 fructose-specific PTS transporter subunit EIIC -
BV131_RS02530 510997..511938 - 942 WP_014550407.1 1-phosphofructokinase -
BV131_RS02535 511940..513439 - 1500 WP_050822813.1 fused PTS fructose transporter subunit IIA/HPr protein -
BV131_RS02540 513511..514041 - 531 WP_005686915.1 hypothetical protein -
BV131_RS02545 514134..514271 - 138 WP_005686917.1 hypothetical protein Toxin
BV131_RS02550 514280..514462 - 183 WP_050822814.1 DUF5397 family protein Antitoxin
BV131_RS02555 514534..515832 - 1299 WP_014550404.1 hemolysin family protein -
BV131_RS02560 515883..516407 - 525 WP_005686921.1 DUF1523 family protein -
BV131_RS02565 516434..517216 - 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
BV131_RS02570 517271..518254 - 984 WP_014550403.1 DNA polymerase III subunit delta' -
BV131_RS02575 518251..518883 - 633 WP_005686927.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-60)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T73717 WP_005686917.1 NZ_CP020010:c514271-514134 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T73717 NZ_CP020010:c514271-514134 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6730.71 Da        Isoelectric Point: 3.9930

>AT73717 WP_050822814.1 NZ_CP020010:c514462-514280 [Haemophilus influenzae]
MELRQQIPTGCIKQFGVPYVVGEVAEFLLDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 183 bp

>AT73717 NZ_CP020010:c514462-514280 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGTTGCGGAATT
TTTGCTAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTATCTCACCTAC
TTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure

References