Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 387347..387984 Replicon chromosome
Accession NZ_CP020010
Organism Haemophilus influenzae strain 67P38H1

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag BV131_RS01890 Protein ID WP_005659980.1
Coordinates 387580..387984 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag BV131_RS01885 Protein ID WP_005656316.1
Coordinates 387347..387583 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV131_RS01860 382575..383315 - 741 WP_005649034.1 YebC/PmpR family DNA-binding transcriptional regulator -
BV131_RS01865 383475..383951 - 477 WP_005686755.1 dihydroneopterin triphosphate diphosphatase -
BV131_RS01870 383973..385739 - 1767 WP_014550472.1 aspartate--tRNA ligase -
BV131_RS01875 385958..386476 + 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
BV131_RS01880 386529..387254 + 726 WP_042611719.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
BV131_RS01885 387347..387583 + 237 WP_005656316.1 antitoxin Antitoxin
BV131_RS01890 387580..387984 + 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
BV131_RS01895 388051..388458 + 408 WP_014550469.1 lactoylglutathione lyase -
BV131_RS01900 388532..389221 + 690 WP_005659978.1 ribonuclease T -
BV131_RS01905 389536..390888 + 1353 WP_005649062.1 Na+/H+ antiporter family protein -
BV131_RS01910 390921..391508 + 588 WP_014550467.1 primosomal replication protein -
BV131_RS01920 391860..392426 - 567 WP_005544066.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T73716 WP_005659980.1 NZ_CP020010:387580-387984 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

>T73716 NZ_CP020010:387580-387984 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT73716 WP_005656316.1 NZ_CP020010:387347-387583 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp

>AT73716 NZ_CP020010:387347-387583 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References