Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1354144..1354733 Replicon chromosome
Accession NZ_CP020009
Organism Haemophilus influenzae strain 5P54H1

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag BV122_RS06795 Protein ID WP_005653200.1
Coordinates 1354144..1354392 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag BV122_RS06800 Protein ID WP_005653201.1
Coordinates 1354389..1354733 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV122_RS06770 1349624..1350256 + 633 WP_005660550.1 energy-coupling factor transporter transmembrane protein EcfT -
BV122_RS06775 1350258..1350884 + 627 WP_105182693.1 energy-coupling factor ABC transporter ATP-binding protein -
BV122_RS06780 1350991..1352181 - 1191 WP_005657030.1 aspartate/tyrosine/aromatic aminotransferase -
BV122_RS06785 1352321..1353409 - 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
BV122_RS06790 1353479..1353973 - 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
BV122_RS06795 1354144..1354392 + 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
BV122_RS06800 1354389..1354733 + 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BV122_RS06805 1354777..1357386 + 2610 WP_105182694.1 aminopeptidase N -
BV122_RS06810 1357458..1358072 - 615 WP_042599650.1 riboflavin synthase -
BV122_RS06815 1358116..1359510 + 1395 WP_105182695.1 sodium-coupled multidrug efflux MATE transporter HmrM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T73714 WP_005653200.1 NZ_CP020009:1354144-1354392 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T73714 NZ_CP020009:1354144-1354392 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT73714 WP_005653201.1 NZ_CP020009:1354389-1354733 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT73714 NZ_CP020009:1354389-1354733 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References