Detailed information of TA system TA073710

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 355963..356600
• Replicon: chromosome
• Accession: NZ_CP020009
• Organism: Haemophilus influenzae strain 5P54H1

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: E4QWH2
• Locus tag: BV122_RS01740
• Protein ID: WP_005649049.1
• Coordinates: 356196..356600 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: E4QWH3
• Locus tag: BV122_RS01735
• Protein ID: WP_005649046.1
• Coordinates: 355963..356199 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV122_RS01710	351342..352082	-	741	WP_005649034.1	YebC/PmpR family DNA-binding transcriptional regulator	-
BV122_RS01715	352094..352567	-	474	WP_011271985.1	dihydroneopterin triphosphate diphosphatase	-
BV122_RS01720	352589..354355	-	1767	WP_042594297.1	aspartate--tRNA ligase	-
BV122_RS01725	354574..355092	+	519	WP_005649040.1	isoprenylcysteine carboxyl methyltransferase family protein	-
BV122_RS01730	355145..355870	+	726	WP_011271987.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
BV122_RS01735	355963..356199	+	237	WP_005649046.1	antitoxin	Antitoxin
BV122_RS01740	356196..356600	+	405	WP_005649049.1	type II toxin-antitoxin system VapC family toxin	Toxin
BV122_RS01745	356667..357074	+	408	WP_005688980.1	lactoylglutathione lyase	-
BV122_RS01750	357148..357837	+	690	WP_011271988.1	ribonuclease T	-
BV122_RS01755	358151..359503	+	1353	WP_005694344.1	Na+/H+ antiporter family protein	-
BV122_RS01760	359536..360123	+	588	WP_005654063.1	primosomal replication protein	-
BV122_RS01770	360474..361040	-	567	WP_005544066.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (6-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15692.29 Da
• Isoelectric Point: 8.9777

>T73710 WP_005649049.1 NZ_CP020009:356196-356600 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Nucleotide

• Length: 405 bp

>T73710 NZ_CP020009:356196-356600 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTATTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATGAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTGGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTGAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGCGACCTATCGGAAATAATGATCTATGGATCGCTTGTCACGCATT
GAGTTTAAATGCCGTTCTTATTACACATAATGTAAAAGAATTTCAGCGAATTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9037.19 Da
• Isoelectric Point: 4.2342

>AT73710 WP_005649046.1 NZ_CP020009:355963-356199 [Haemophilus influenzae]
MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Nucleotide

• Length: 237 bp

>AT73710 NZ_CP020009:355963-356199 [Haemophilus influenzae]
ATGCTTACTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGACGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Structures

Toxin

• AlphaFold DB: E4QWH2

Antitoxin

• AlphaFold DB: E4QWH3