Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1354290..1354879 Replicon chromosome
Accession NZ_CP020008
Organism Haemophilus influenzae strain 5P28H1

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag BV121_RS06785 Protein ID WP_005653200.1
Coordinates 1354290..1354538 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag BV121_RS06790 Protein ID WP_005653201.1
Coordinates 1354535..1354879 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV121_RS06760 1349770..1350402 + 633 WP_005660550.1 energy-coupling factor transporter transmembrane protein EcfT -
BV121_RS06765 1350404..1351030 + 627 WP_105182693.1 energy-coupling factor ABC transporter ATP-binding protein -
BV121_RS06770 1351137..1352327 - 1191 WP_005657030.1 aspartate/tyrosine/aromatic aminotransferase -
BV121_RS06775 1352467..1353555 - 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
BV121_RS06780 1353625..1354119 - 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
BV121_RS06785 1354290..1354538 + 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
BV121_RS06790 1354535..1354879 + 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BV121_RS06795 1354923..1357532 + 2610 WP_105182694.1 aminopeptidase N -
BV121_RS06800 1357604..1358218 - 615 WP_042599650.1 riboflavin synthase -
BV121_RS06805 1358262..1359656 + 1395 WP_105182695.1 sodium-coupled multidrug efflux MATE transporter HmrM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T73708 WP_005653200.1 NZ_CP020008:1354290-1354538 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

>T73708 NZ_CP020008:1354290-1354538 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGTTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCGAACATACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGTGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT73708 WP_005653201.1 NZ_CP020008:1354535-1354879 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp

>AT73708 NZ_CP020008:1354535-1354879 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTGTTTGGCAAACTTGC
TTACATTCGTGATTTAGTGACTTACGAAGCAGAGTCATTATCTGAGCTAGAAAAAGAATTTCGTCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCTACGATCATAGCAGGCGATCGTTCTCTTAATGCTTTTGTTACGGAAGCGATTCAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References