Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1061075..1061706 Replicon chromosome
Accession NZ_CP020008
Organism Haemophilus influenzae strain 5P28H1

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag BV121_RS05370 Protein ID WP_005651560.1
Coordinates 1061075..1061473 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag BV121_RS05375 Protein ID WP_005648011.1
Coordinates 1061473..1061706 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV121_RS05350 1056258..1057376 + 1119 WP_011272304.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
BV121_RS05355 1057377..1058399 + 1023 WP_005693292.1 outer membrane-stress sensor serine endopeptidase DegS -
BV121_RS05360 1058473..1059288 - 816 WP_011272305.1 DNA-formamidopyrimidine glycosylase -
BV121_RS05365 1059520..1061055 - 1536 WP_011272306.1 L-2,4-diaminobutyrate decarboxylase -
BV121_RS05370 1061075..1061473 - 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
BV121_RS05375 1061473..1061706 - 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
BV121_RS05380 1061853..1063217 - 1365 WP_005651563.1 diaminobutyrate--2-oxoglutarate transaminase -
BV121_RS05385 1063564..1063734 - 171 WP_005613503.1 50S ribosomal protein L33 -
BV121_RS05390 1063746..1063982 - 237 WP_005542826.1 50S ribosomal protein L28 -
BV121_RS05395 1064196..1064861 - 666 WP_013526173.1 DNA repair protein RadC -
BV121_RS05400 1065024..1066226 + 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T73707 WP_005651560.1 NZ_CP020008:c1061473-1061075 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

>T73707 NZ_CP020008:c1061473-1061075 [Haemophilus influenzae]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT73707 WP_005648011.1 NZ_CP020008:c1061706-1061473 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp

>AT73707 NZ_CP020008:c1061706-1061473 [Haemophilus influenzae]
ATGATTGAAGCCTCTGTTTTTATGACTAATCGAAGTCAAGCTGTGCGTTTGCCCGCTGAAGTTCGCTTTTCTGAAGAAAT
CAAAAAATTATCGGTTCGTGTATCGGGCAGTGATCGGATTTTATCGCCTCTCAACCAATCTTGGGATAGTTTTTTCTTGA
ATGATCAAGCAGTTAGCGATGATTTTATGAATGAACGAGAAATTGCATTTCAACCAGAGCGTGAGGCTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References