Detailed information of TA system TA073702

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1365084..1365673
• Replicon: chromosome
• Accession: NZ_CP020007
• Organism: Haemophilus influenzae strain 48P153H1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q709A1
• Locus tag: BV085_RS06820
• Protein ID: WP_005686594.1
• Coordinates: 1365084..1365332 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q9R3K0
• Locus tag: BV085_RS06825
• Protein ID: WP_005686595.1
• Coordinates: 1365329..1365673 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV085_RS06795	1360566..1361198	+	633	WP_005686586.1	energy-coupling factor transporter transmembrane protein EcfT	-
BV085_RS06800	1361200..1361826	+	627	WP_005686589.1	energy-coupling factor ABC transporter ATP-binding protein	-
BV085_RS06805	1361931..1363121	-	1191	WP_005686591.1	aspartate/tyrosine/aromatic aminotransferase	-
BV085_RS06810	1363261..1364349	-	1089	WP_005686592.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
BV085_RS06815	1364419..1364913	-	495	WP_005686593.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
BV085_RS06820	1365084..1365332	+	249	WP_005686594.1	type II toxin-antitoxin system HicA family toxin	Toxin
BV085_RS06825	1365329..1365673	+	345	WP_005686595.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BV085_RS06830	1366065..1368674	+	2610	WP_005686596.1	aminopeptidase N	-
BV085_RS06835	1368746..1369360	-	615	WP_005657019.1	riboflavin synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-81)

Antitoxin

• Uncharacterised protein family HicB (54-102)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9396.93 Da
• Isoelectric Point: 10.7140

>T73702 WP_005686594.1 NZ_CP020007:1365084-1365332 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELASLLAQQGYEKREMAGSRVRFYNRTLKHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Nucleotide

• Length: 249 bp

>T73702 NZ_CP020007:1365084-1365332 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGCTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCAAGCACACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 13123.03 Da
• Isoelectric Point: 5.0042

>AT73702 WP_005686595.1 NZ_CP020007:1365329-1365673 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFHQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIKEKIFREKPSLR

Nucleotide

• Length: 345 bp

>AT73702 NZ_CP020007:1365329-1365673 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTATTTGGCAAACTTGC
TTACATTCGTGATTTAGTAACTTACGAAGCAGAGTCATTATCTGAGTTAGAAAAAGAATTTCATCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCAACGATCATAGCTGGCGATCGTTCTCTTAATGCTTTTGTGACGGAAGCAATTAAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Structures

Toxin

• AlphaFold DB: Q709A1

Antitoxin

• AlphaFold DB: Q9R3K0