Detailed information of TA system TA073693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1365265..1365854
• Replicon: chromosome
• Accession: NZ_CP020006
• Organism: Haemophilus influenzae strain 48P106H1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q709A1
• Locus tag: BV083_RS06815
• Protein ID: WP_005686594.1
• Coordinates: 1365265..1365513 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q9R3K0
• Locus tag: BV083_RS06820
• Protein ID: WP_005686595.1
• Coordinates: 1365510..1365854 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BV083_RS06790	1360747..1361379	+	633	WP_005686586.1	energy-coupling factor transporter transmembrane protein EcfT	-
BV083_RS06795	1361381..1362007	+	627	WP_005686589.1	energy-coupling factor ABC transporter ATP-binding protein	-
BV083_RS06800	1362112..1363302	-	1191	WP_005686591.1	aspartate/tyrosine/aromatic aminotransferase	-
BV083_RS06805	1363442..1364530	-	1089	WP_005686592.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
BV083_RS06810	1364600..1365094	-	495	WP_005686593.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
BV083_RS06815	1365265..1365513	+	249	WP_005686594.1	type II toxin-antitoxin system HicA family toxin	Toxin
BV083_RS06820	1365510..1365854	+	345	WP_005686595.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BV083_RS06825	1366246..1368855	+	2610	WP_005686596.1	aminopeptidase N	-
BV083_RS06830	1368927..1369541	-	615	WP_005657019.1	riboflavin synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-81)

Antitoxin

• Uncharacterised protein family HicB (54-102)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 9396.93 Da
• Isoelectric Point: 10.7140

>T73693 WP_005686594.1 NZ_CP020006:1365265-1365513 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELASLLAQQGYEKREMAGSRVRFYNRTLKHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Nucleotide

• Length: 249 bp

>T73693 NZ_CP020006:1365265-1365513 [Haemophilus influenzae]
ATGGGACGAACTGAAAAATTATTAGATAAGCTCGCACAATCAAAATCTACATTTAATTGGAATGAATTAGCTTCTTTGTT
AGCTCAACAAGGTTATGAAAAGCGAGAAATGGCAGGCTCTCGAGTGAGATTTTATAATAGAACACTCAAGCACACGATTT
TGTTACACAAGCCTCACCCTGAAAATTATATTAAAGGCGGTGCTTTAAAGTCAGTGAAAGAATCATTAAAACAGGTAGGT
ATTCTATGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 13123.03 Da
• Isoelectric Point: 5.0042

>AT73693 WP_005686595.1 NZ_CP020006:1365510-1365854 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFHQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIKEKIFREKPSLR

Nucleotide

• Length: 345 bp

>AT73693 NZ_CP020006:1365510-1365854 [Haemophilus influenzae]
ATGAAGTTATTAAATTATAAAGGTTATGTTGGCACGATTGAGGCGGATTTAGAAAACAATATATTATTTGGCAAACTTGC
TTACATTCGTGATTTAGTAACTTACGAAGCAGAGTCATTATCTGAGTTAGAAAAAGAATTTCATCAATCTGTTGATTTAT
ATTTACAAGATTGTTTGGAATTAGGTAAAGAACCGAATAAGCCTTTTAAAGGTGTATTTAATGTACGAATTGGCGAGGAA
TTGCATAGAGAAGCAACGATCATAGCTGGCGATCGTTCTCTTAATGCTTTTGTGACGGAAGCAATTAAAGAAAAAATTTT
TCGTGAAAAACCAAGTTTAAGATAA

Structures

Toxin

• AlphaFold DB: Q709A1

Antitoxin

• AlphaFold DB: Q9R3K0