Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1051563..1052097 Replicon chromosome
Accession NZ_CP020006
Organism Haemophilus influenzae strain 48P106H1

Toxin (Protein)


Gene name relE Uniprot ID A0A2R3GCN3
Locus tag BV083_RS05255 Protein ID WP_005651512.1
Coordinates 1051563..1051853 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A5Y2
Locus tag BV083_RS05260 Protein ID WP_005651514.1
Coordinates 1051843..1052097 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV083_RS05240 1048908..1049411 + 504 WP_005659127.1 hypothetical protein -
BV083_RS05245 1049411..1050445 + 1035 WP_005659128.1 DNA polymerase III subunit delta -
BV083_RS09180 1050966..1051103 - 138 WP_005659136.1 hypothetical protein -
BV083_RS05250 1051273..1051482 - 210 WP_074030365.1 hypothetical protein -
BV083_RS05255 1051563..1051853 - 291 WP_005651512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV083_RS05260 1051843..1052097 - 255 WP_005651514.1 stability protein StbD Antitoxin
BV083_RS05270 1052395..1052619 - 225 WP_005659141.1 hypothetical protein -
BV083_RS05275 1052619..1052927 - 309 WP_005659142.1 P2 family phage major capsid protein -
BV083_RS05280 1052957..1053496 - 540 WP_005659144.1 hypothetical protein -
BV083_RS05290 1053858..1055924 - 2067 WP_005686190.1 glycine--tRNA ligase subunit beta -
BV083_RS05295 1056262..1056627 - 366 WP_005686191.1 endonuclease domain-containing protein -
BV083_RS05300 1056657..1056917 - 261 WP_005663579.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11482.41 Da        Isoelectric Point: 10.6484

>T73691 WP_005651512.1 NZ_CP020006:c1051853-1051563 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

>T73691 NZ_CP020006:c1051853-1051563 [Haemophilus influenzae]
ATGACTTATAAACTCATTTTTGATAAACGCGCATTAAAAGAATGGAATAAATTGGGGGAAACCTTACGCCAACAATTTAA
AAATAAATTAGCCGAAAGAATGATAAATCCACGCATTCAAGCCGACAAATTAAAGGGCGAAAATGATTTATATAAAATCA
AATTAAGAAGCGCTGGTTATCGATTAGTTTATCAAGTAAGAGATCAGGAAATCACTATTATTGTTGTATCTGTTGGAAAA
AGGGAACGATTAGAAGTCTATAAAACCGCAGAACAAAGAACAGCCCACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9419.78 Da        Isoelectric Point: 4.0737

>AT73691 WP_005651514.1 NZ_CP020006:c1052097-1051843 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp

>AT73691 NZ_CP020006:c1052097-1051843 [Haemophilus influenzae]
ATGGCATTACATCAAATACTGGCAGAACAAGCGGCAAGCATTACAGACTTAAAACGAAACCCAATGGGCGTAATTCAAGA
AAGCGAAAGCGGAATAGTCGCAATATTGAACCGAAACCAACCCGCATTTTATTGCATCACCCCCGAATTATTCTCTCATA
TGCAAGAATTAATCGAAGATTTAGAGCTCGGCAGAATGGCAAATGAACGGCTAGCCACCCTAGAACCAGTAGAGGTTGAT
CTAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3GCN3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYX4

References