Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 821222..821826 Replicon chromosome
Accession NZ_CP020006
Organism Haemophilus influenzae strain 48P106H1

Toxin (Protein)


Gene name relE Uniprot ID A0A112W1Q1
Locus tag BV083_RS04085 Protein ID WP_005661261.1
Coordinates 821518..821826 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Y7JSS2
Locus tag BV083_RS04080 Protein ID WP_005661259.1
Coordinates 821222..821518 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV083_RS04065 816988..818373 + 1386 WP_005687866.1 L-seryl-tRNA(Sec) selenium transferase -
BV083_RS04070 818370..820229 + 1860 WP_005687864.1 selenocysteine-specific translation elongation factor -
BV083_RS04075 820248..821102 + 855 WP_005687862.1 DUF3298 domain-containing protein -
BV083_RS04080 821222..821518 + 297 WP_005661259.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BV083_RS04085 821518..821826 + 309 WP_005661261.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BV083_RS04090 821882..825196 - 3315 WP_105210539.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
BV083_RS04095 825499..826797 + 1299 WP_005658620.1 trigger factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(7-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11895.63 Da        Isoelectric Point: 7.3189

>T73690 WP_005661261.1 NZ_CP020006:821518-821826 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T73690 NZ_CP020006:821518-821826 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTGAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGTTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATACACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGTGATTTGGTACTGATTTACCAATACGTT
ATACAGGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11015.37 Da        Isoelectric Point: 4.4297

>AT73690 WP_005661259.1 NZ_CP020006:821222-821518 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT73690 NZ_CP020006:821222-821518 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGAAAACAAAATTAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCCTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTCTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A112W1Q1

Antitoxin

Source ID Structure
AlphaFold DB A0A0Y7JSS2

References