Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 562670..563007 Replicon chromosome
Accession NZ_CP020006
Organism Haemophilus influenzae strain 48P106H1

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag BV083_RS02765 Protein ID WP_005686917.1
Coordinates 562670..562807 (-) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag BV083_RS02770 Protein ID WP_005649350.1
Coordinates 562816..563007 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV083_RS02745 557861..559531 - 1671 WP_005686908.1 fructose-specific PTS transporter subunit EIIC -
BV083_RS02750 559533..560474 - 942 WP_005686910.1 1-phosphofructokinase -
BV083_RS02755 560476..561975 - 1500 WP_005686912.1 fused PTS fructose transporter subunit IIA/HPr protein -
BV083_RS02760 562047..562577 - 531 WP_005686915.1 hypothetical protein -
BV083_RS02765 562670..562807 - 138 WP_005686917.1 hypothetical protein Toxin
BV083_RS02770 562816..563007 - 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
BV083_RS02775 563079..564377 - 1299 WP_032821624.1 hemolysin family protein -
BV083_RS02780 564428..564952 - 525 WP_005686921.1 DUF1523 family protein -
BV083_RS02785 564979..565761 - 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
BV083_RS02790 565816..566799 - 984 WP_005686925.1 DNA polymerase III subunit delta' -
BV083_RS02795 566796..567428 - 633 WP_005686927.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T73687 WP_005686917.1 NZ_CP020006:c562807-562670 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T73687 NZ_CP020006:c562807-562670 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT73687 WP_005649350.1 NZ_CP020006:c563007-562816 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT73687 NZ_CP020006:c563007-562816 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References