Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2037418..2039054 Replicon chromosome
Accession NZ_CP020000
Organism Acinetobacter calcoaceticus strain CA16

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BUM88_RS09905 Protein ID WP_080027109.1
Coordinates 2037723..2039054 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BUM88_RS09900 Protein ID WP_005040627.1
Coordinates 2037418..2037726 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUM88_RS09885 2032642..2033409 - 768 WP_080027106.1 SDR family oxidoreductase -
BUM88_RS09890 2033485..2034783 - 1299 WP_080027107.1 MFS transporter -
BUM88_RS09895 2035058..2037319 + 2262 WP_080027108.1 excinuclease ABC subunit UvrA -
BUM88_RS09900 2037418..2037726 - 309 WP_005040627.1 helix-turn-helix domain-containing protein Antitoxin
BUM88_RS09905 2037723..2039054 - 1332 WP_080027109.1 HipA domain-containing protein Toxin
BUM88_RS09910 2039272..2041044 - 1773 WP_080027110.1 amidohydrolase -
BUM88_RS20040 2041134..2041283 - 150 WP_167370592.1 hypothetical protein -
BUM88_RS09915 2041567..2042562 + 996 WP_080027111.1 putative multidrug efflux protein AdeT1 -
BUM88_RS09920 2042623..2043141 - 519 WP_080027112.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50876.83 Da        Isoelectric Point: 5.1421

>T73683 WP_080027109.1 NZ_CP020000:c2039054-2037723 [Acinetobacter calcoaceticus]
MKKLTIQALLDANWLDIAELKLLESKQGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILVKHESSTWFGFLDDIVP
SGAARRYWVNYLDLQRLTHAEQDSILLEKGGIAPVGNLRIKEALPPINPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQETFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQVLNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWRNQQWHRHGLESVYSVLNKSSGSHLNHFEVIEDLCRLLSSIDSDFDASQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKISLSPIYDFAPMKADPEVVTRSMTWGSPYEEGGEYRWTQITQKLAPWCDPDLSLGTLK
SLAINLLGLKQRLVDKGVPKKIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T73683 NZ_CP020000:c2039054-2037723 [Acinetobacter calcoaceticus]
ATGAAAAAATTAACAATACAAGCACTACTTGATGCGAACTGGTTAGATATAGCAGAACTAAAATTATTAGAGTCTAAACA
GGGCTCGGCGAGTGCAAGTGAATTAGAGTATGAATTGGATTATGCAATTCAATATTTAGACAGGCGGGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATACTTGTAAAACATGAATCGAGCACATGGTTTGGTTTTTTAGATGATATCGTGCCT
TCTGGTGCTGCACGACGTTATTGGGTGAATTATCTAGATTTACAACGTTTAACCCATGCCGAGCAAGATAGTATCTTATT
AGAAAAAGGGGGAATTGCTCCTGTTGGTAATTTACGGATTAAAGAAGCACTTCCACCTATAAATCCAGAATCAACCTTAC
ACTTACGTTATTTTAGCAAAGAAGATGTTGCTGAGCGGAATATTGATTTTCTGGAATATGCTCAGCAAATGGGTGCCATT
AGTGGTGGTGCAACTGGCGCAGGCGGGGAAGCTCCCAAATTACTTATCCGTGTTTCACCAGAACAAAAAGTCTGGATTGA
TACCTACCAAGAAACTTTTGATCAGCCAGATCAACATTATTTAGTTAAGTTTCCGAGAAATAAACGTAGCGAGATTGATT
GTGACATTCTCAGAGCCGAATATTATTACTATCAGGTACTCAATGAATTAGGTTTCAATACGATTGAAACAACACAAATG
AAGCTCATTGAAGGTACAAAGTATCCTTCTTTGTGGCTACCAAGGTTTGATACAGAATGGCGTAATCAACAATGGCATCG
CCATGGCTTAGAATCTGTTTATTCGGTGCTAAATAAATCTTCTGGTAGTCATCTTAACCATTTTGAAGTGATTGAAGATC
TATGTAGATTACTGAGTAGCATTGATTCAGATTTTGATGCTTCACAATTCATTTGTGAGTGGTTACAAAGAGACTTACTC
AATATTATTTTCGGTAATTCAGACAATCATGGTCGCAATACATCATTTCTAAAAAAATCTGGAAAAATTTCTCTTTCACC
TATTTACGATTTTGCACCTATGAAAGCCGATCCAGAAGTTGTGACCAGATCGATGACTTGGGGAAGTCCGTATGAAGAAG
GAGGTGAATACCGTTGGACTCAAATTACTCAAAAACTTGCGCCTTGGTGTGATCCTGATTTATCTCTAGGAACATTAAAG
TCTTTGGCAATTAATCTGCTTGGGCTAAAACAGCGATTAGTTGATAAAGGAGTACCGAAAAAAATTATTGAAATGCCAGC
GCTATCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11504.43 Da        Isoelectric Point: 10.0639

>AT73683 WP_005040627.1 NZ_CP020000:c2037726-2037418 [Acinetobacter calcoaceticus]
MNIKNQTQDRQQVLIDLYKQYLLSEITLGQLLSHLRKNVLGLSQEQYAALVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVGKIIKPSE

Download         Length: 309 bp

>AT73683 NZ_CP020000:c2037726-2037418 [Acinetobacter calcoaceticus]
ATGAATATAAAAAATCAGACTCAAGACCGTCAGCAAGTTCTTATCGATTTATATAAACAATATTTATTGAGTGAGATTAC
GCTGGGACAATTGCTGTCACATTTGCGAAAGAATGTACTGGGTTTGTCACAAGAACAATATGCTGCTTTAGTCGGGATAA
GTCGTCGGACATTAACTGATATTGAGCAGGACAAAGGTAAACTTACTCAATCAGTGTTAGATAAGGTGTTTAAGCCACTG
GGTTTAAAAGCAGGTCTTGTACCTACGCATGAACATATTGTTGGCAAAATTATAAAGCCATCCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References