Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1658929..1659582 Replicon chromosome
Accession NZ_CP020000
Organism Acinetobacter calcoaceticus strain CA16

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BUM88_RS08155 Protein ID WP_080026899.1
Coordinates 1658929..1659111 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BUM88_RS08160 Protein ID WP_080026900.1
Coordinates 1659178..1659582 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUM88_RS08100 1654298..1654687 + 390 WP_080026888.1 hypothetical protein -
BUM88_RS08105 1654689..1655057 + 369 WP_080026889.1 glutamate 5-kinase -
BUM88_RS08110 1655241..1655615 + 375 WP_080026890.1 hypothetical protein -
BUM88_RS08115 1655617..1655838 + 222 WP_080026891.1 hypothetical protein -
BUM88_RS08120 1655810..1656178 + 369 WP_080026892.1 hypothetical protein -
BUM88_RS08125 1656180..1656578 + 399 WP_167370591.1 hypothetical protein -
BUM88_RS08130 1656580..1656771 + 192 WP_080026894.1 hypothetical protein -
BUM88_RS08135 1656768..1656974 + 207 WP_080026895.1 hypothetical protein -
BUM88_RS08140 1657083..1658012 + 930 WP_080026896.1 hypothetical protein -
BUM88_RS08145 1658064..1658597 + 534 WP_080026897.1 hypothetical protein -
BUM88_RS08155 1658929..1659111 + 183 WP_080026899.1 type II toxin-antitoxin system HicA family toxin Toxin
BUM88_RS08160 1659178..1659582 + 405 WP_080026900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BUM88_RS08165 1659662..1660132 + 471 WP_080026901.1 hypothetical protein -
BUM88_RS08170 1660323..1664447 + 4125 WP_080028247.1 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1618874..1686514 67640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6751.00 Da        Isoelectric Point: 10.7473

>T73682 WP_080026899.1 NZ_CP020000:1658929-1659111 [Acinetobacter calcoaceticus]
VKSLDLVKMIEADGWYLDRIKGSHHHFKHPTKKGIVTIPHPKKDLPSGTVKNILKQAGLK

Download         Length: 183 bp

>T73682 NZ_CP020000:1658929-1659111 [Acinetobacter calcoaceticus]
GTGAAAAGTCTGGATTTAGTCAAAATGATTGAAGCAGACGGTTGGTATTTGGACAGGATTAAAGGTAGTCATCATCACTT
TAAACATCCAACCAAAAAGGGAATAGTTACTATCCCTCATCCTAAAAAGGATTTACCAAGCGGAACTGTTAAGAACATTT
TGAAGCAAGCGGGTCTAAAGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14599.69 Da        Isoelectric Point: 4.3954

>AT73682 WP_080026900.1 NZ_CP020000:1659178-1659582 [Acinetobacter calcoaceticus]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDLVDYLGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIHIIDENVGKGKRYKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT73682 NZ_CP020000:1659178-1659582 [Acinetobacter calcoaceticus]
ATGTTGTATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCACAGTTCCAGATATTCCTGGATGTTT
TAGCGCAGGCGACACATTAGAGGAAGCTATCGAGAACGTTAAAGAGGCTATTTCAGGACATTTAGAAATCTTAGCTGAAG
ATGGTGAGGAAATTCCATTAGCATCTGATGTAAGTAAGTTTATAGATCTAGTTGATTATTTAGGTATGATCTGGGCAGTG
ACTGAGGTTGATGTAAGCCGCTACTTGGGCAAGCCAGAAAAAATCAATGTAACTTTACCAAGTCGTTTAATCCATATAAT
TGATGAAAATGTAGGTAAAGGTAAGAGATATAAGACTCGATCTGCCTTTTTGGCCGCTGGTGCCGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References