Detailed information of TA system TA073679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/DUF433(antitoxin)
• Location: 2437595..2438166
• Replicon: chromosome
• Accession: NZ_CP019998
• Organism: Arthrospira platensis C1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: APLC1_RS11850
• Protein ID: WP_006624723.1
• Coordinates: 2437825..2438166 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B5W521
• Locus tag: APLC1_RS11845
• Protein ID: WP_006624722.1
• Coordinates: 2437595..2437828 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APLC1_RS11795 (APLC1_2543)	2433439..2434269	+	831	WP_006624709.1	nitrate ABC transporter ATP-binding protein	-
APLC1_RS11800 (APLC1_2544)	2434357..2434509	+	153	WP_228116363.1	hypothetical protein	-
APLC1_RS11805	2434529..2434699	-	171	WP_260378917.1	hypothetical protein	-
APLC1_RS11810 (APLC1_2545)	2434796..2435008	+	213	WP_006624713.1	type II toxin-antitoxin system VapB family antitoxin	-
APLC1_RS11815 (APLC1_2546)	2434995..2435402	+	408	WP_006624714.1	PIN domain nuclease	-
APLC1_RS11820 (APLC1_2547)	2435624..2435836	-	213	WP_006624715.1	hypothetical protein	-
APLC1_RS11825 (APLC1_2549)	2436057..2436263	-	207	WP_006624717.1	hypothetical protein	-
APLC1_RS11830 (APLC1_2550)	2436409..2436792	-	384	WP_006624719.1	type II toxin-antitoxin system VapC family toxin	-
APLC1_RS11835 (APLC1_2551)	2436785..2437021	-	237	WP_006624720.1	hypothetical protein	-
APLC1_RS11840	2437150..2437428	+	279	WP_006624721.1	hypothetical protein	-
APLC1_RS11845 (APLC1_2552)	2437595..2437828	+	234	WP_006624722.1	DUF433 domain-containing protein	Antitoxin
APLC1_RS11850 (APLC1_2553)	2437825..2438166	+	342	WP_006624723.1	DUF5615 family PIN-like protein	Toxin
APLC1_RS11855 (APLC1_2554)	2438297..2438527	-	231	WP_006624724.1	hypothetical protein	-
APLC1_RS11860 (APLC1_2555)	2438515..2438829	-	315	WP_006624725.1	hypothetical protein	-
APLC1_RS11865	2438968..2439210	+	243	WP_006624726.1	hypothetical protein	-
APLC1_RS11870 (APLC1_2556)	2439240..2439476	+	237	WP_006624727.1	hypothetical protein	-
APLC1_RS11875 (APLC1_2557)	2439479..2439883	+	405	WP_006624728.1	PIN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Domain of unknown function DUF5615 (1-78)

Antitoxin

• Protein of unknown function DUF433 (11-66)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12622.57 Da
• Isoelectric Point: 4.2821

>T73679 WP_006624723.1 NZ_CP019998:2437825-2438166 [Arthrospira platensis C1]
MKIWVDAQLPPTLASWLTETFGLEASALRDLGWRDAQDIEIFAAARSENVVIVTKDSDFIDLVCRLGSPPQILWLTCGNV
TNRNLRKLLMATLPNALEQLQQGEMIVEITNTP

Nucleotide

• Length: 342 bp

>T73679 NZ_CP019998:2437825-2438166 [Arthrospira platensis C1]
ATGAAAATTTGGGTCGATGCTCAACTTCCGCCTACGTTGGCAAGTTGGCTGACAGAAACCTTTGGTTTAGAAGCGAGTGC
ATTGCGGGATTTAGGCTGGCGGGATGCTCAAGATATCGAGATTTTTGCAGCAGCACGGTCTGAAAATGTGGTGATTGTCA
CGAAAGACAGTGATTTTATTGATTTGGTCTGTCGTTTAGGATCGCCTCCTCAAATTTTATGGCTAACTTGTGGCAATGTC
ACGAACCGTAATTTGCGAAAATTGTTAATGGCAACTTTACCGAATGCGTTGGAGCAATTGCAGCAAGGAGAAATGATTGT
GGAAATTACGAATACGCCTTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8595.96 Da
• Isoelectric Point: 4.4644

>AT73679 WP_006624722.1 NZ_CP019998:2437595-2437828 [Arthrospira platensis C1]
MTSTPELMSRITQNPGQCGGRPCIRGMRIRVTDILEMLAENVSISEVLEDFPDLELADIQACLLFAARRTDFPRLTA

Nucleotide

• Length: 234 bp

>AT73679 NZ_CP019998:2437595-2437828 [Arthrospira platensis C1]
ATGACTTCAACTCCTGAATTAATGAGCCGAATTACGCAAAATCCCGGTCAATGTGGGGGTCGTCCCTGTATTCGCGGGAT
GCGAATTAGAGTCACCGATATTTTAGAAATGTTAGCGGAAAATGTGAGCATTTCTGAAGTTTTAGAAGATTTTCCCGATT
TAGAACTAGCAGATATTCAAGCCTGTCTGCTGTTTGCGGCAAGACGTACTGATTTTCCCAGACTCACCGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A7G7VPN8