Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/- |
| Location | 522043..522637 | Replicon | chromosome |
| Accession | NZ_CP019998 | ||
| Organism | Arthrospira platensis C1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | B5W837 |
| Locus tag | APLC1_RS02710 | Protein ID | WP_006622859.1 |
| Coordinates | 522278..522637 (+) | Length | 120 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | B5W838 |
| Locus tag | APLC1_RS02705 | Protein ID | WP_006622858.1 |
| Coordinates | 522043..522288 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| APLC1_RS02675 (APLC1_0560) | 517079..517444 | - | 366 | WP_006617433.1 | ferredoxin-thioredoxin reductase catalytic domain-containing protein | - |
| APLC1_RS02680 (APLC1_0561) | 517559..518101 | - | 543 | WP_006622854.1 | cyclic nucleotide-binding domain-containing protein | - |
| APLC1_RS02685 (APLC1_0562) | 518252..518725 | - | 474 | WP_260378610.1 | tetratricopeptide repeat protein | - |
| APLC1_RS02690 (APLC1_0563) | 518734..519069 | - | 336 | WP_260378611.1 | thioredoxin domain-containing protein | - |
| APLC1_RS02695 (APLC1_0564) | 519123..520394 | - | 1272 | WP_006622856.1 | hypothetical protein | - |
| APLC1_RS02700 (APLC1_0566) | 520498..521731 | + | 1234 | Protein_536 | DUF4336 domain-containing protein | - |
| APLC1_RS02705 (APLC1_0567) | 522043..522288 | + | 246 | WP_006622858.1 | hypothetical protein | Antitoxin |
| APLC1_RS02710 (APLC1_0568) | 522278..522637 | + | 360 | WP_006622859.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| APLC1_RS02715 (APLC1_0569) | 522816..523034 | + | 219 | WP_155839120.1 | hypothetical protein | - |
| APLC1_RS02720 (APLC1_0570) | 523336..523563 | + | 228 | WP_231296476.1 | PIN domain-containing protein | - |
| APLC1_RS02725 (APLC1_0571) | 523553..523765 | + | 213 | WP_006622862.1 | hypothetical protein | - |
| APLC1_RS02730 (APLC1_0572) | 524009..524257 | + | 249 | WP_006622863.1 | UPF0175 family protein | - |
| APLC1_RS02735 (APLC1_0573) | 524269..524418 | + | 150 | WP_006622865.1 | UPF0175 family protein | - |
| APLC1_RS02740 (APLC1_0574) | 524409..524681 | + | 273 | WP_008056114.1 | DUF3368 domain-containing protein | - |
| APLC1_RS02745 (APLC1_0575) | 524834..525220 | - | 387 | WP_006622869.1 | type II toxin-antitoxin system VapC family toxin | - |
| APLC1_RS02750 (APLC1_0576) | 525220..525444 | - | 225 | WP_006622871.1 | DUF2281 domain-containing protein | - |
| APLC1_RS02755 (APLC1_0577) | 525629..525838 | + | 210 | WP_006622874.1 | hypothetical protein | - |
| APLC1_RS02760 (APLC1_0579) | 526115..526303 | + | 189 | WP_006622878.1 | hypothetical protein | - |
| APLC1_RS02765 (APLC1_0580) | 526594..526887 | + | 294 | WP_006622881.1 | type II toxin-antitoxin system HigB family toxin | - |
| APLC1_RS02770 (APLC1_0581) | 526871..527203 | + | 333 | WP_006622883.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 120 a.a. Molecular weight: 13756.68 Da Isoelectric Point: 9.4580
>T73675 WP_006622859.1 NZ_CP019998:522278-522637 [Arthrospira platensis C1]
MPNNPELVNIYFTPEYRDNLKKLAKKYRNIRSDTQGLIEELQKGSVLGDRLSGFGDHLYVYKVRAKNSNIQKGKSAGYRI
IYLLESETSILLLTIYSKSEQEDITKEQIKSILDNFHQA
MPNNPELVNIYFTPEYRDNLKKLAKKYRNIRSDTQGLIEELQKGSVLGDRLSGFGDHLYVYKVRAKNSNIQKGKSAGYRI
IYLLESETSILLLTIYSKSEQEDITKEQIKSILDNFHQA
Download Length: 360 bp
>T73675 NZ_CP019998:522278-522637 [Arthrospira platensis C1]
ATGCCGAATAATCCTGAATTAGTGAACATTTATTTCACACCTGAATATCGTGATAACCTCAAAAAATTAGCCAAAAAATA
TCGAAATATTCGCTCTGATACTCAGGGGTTAATAGAGGAACTCCAAAAAGGCTCGGTGTTAGGCGATCGCCTTTCGGGTT
TTGGTGATCATCTTTATGTTTACAAGGTCAGAGCTAAAAATAGTAATATCCAAAAAGGCAAAAGTGCTGGATATCGCATT
ATTTATTTACTGGAATCAGAAACCAGCATTTTGTTATTGACGATTTATAGTAAATCGGAGCAGGAAGATATTACTAAGGA
GCAAATTAAAAGTATTTTAGATAATTTTCATCAAGCATAG
ATGCCGAATAATCCTGAATTAGTGAACATTTATTTCACACCTGAATATCGTGATAACCTCAAAAAATTAGCCAAAAAATA
TCGAAATATTCGCTCTGATACTCAGGGGTTAATAGAGGAACTCCAAAAAGGCTCGGTGTTAGGCGATCGCCTTTCGGGTT
TTGGTGATCATCTTTATGTTTACAAGGTCAGAGCTAAAAATAGTAATATCCAAAAAGGCAAAAGTGCTGGATATCGCATT
ATTTATTTACTGGAATCAGAAACCAGCATTTTGTTATTGACGATTTATAGTAAATCGGAGCAGGAAGATATTACTAAGGA
GCAAATTAAAAGTATTTTAGATAATTTTCATCAAGCATAG
Antitoxin
Download Length: 82 a.a. Molecular weight: 9114.35 Da Isoelectric Point: 4.0742
>AT73675 WP_006622858.1 NZ_CP019998:522043-522288 [Arthrospira platensis C1]
MKAFEVLGKVNHQGHILLDEPLEVKPDIRVKVIVLISDEDELDADDTPVEEIQASLIRALQDAQAGRRIPLEQMWEGIDA
E
MKAFEVLGKVNHQGHILLDEPLEVKPDIRVKVIVLISDEDELDADDTPVEEIQASLIRALQDAQAGRRIPLEQMWEGIDA
E
Download Length: 246 bp
>AT73675 NZ_CP019998:522043-522288 [Arthrospira platensis C1]
ATGAAGGCATTTGAGGTATTGGGAAAAGTCAATCATCAGGGTCACATTTTGCTAGATGAACCTTTAGAAGTTAAACCTGA
TATTCGGGTCAAAGTTATCGTTTTGATATCTGATGAAGATGAATTGGATGCTGACGATACTCCGGTTGAGGAAATTCAAG
CCAGTTTAATCCGAGCGTTGCAAGATGCTCAAGCCGGAAGAAGAATTCCCCTAGAACAAATGTGGGAGGGAATTGATGCC
GAATAA
ATGAAGGCATTTGAGGTATTGGGAAAAGTCAATCATCAGGGTCACATTTTGCTAGATGAACCTTTAGAAGTTAAACCTGA
TATTCGGGTCAAAGTTATCGTTTTGATATCTGATGAAGATGAATTGGATGCTGACGATACTCCGGTTGAGGAAATTCAAG
CCAGTTTAATCCGAGCGTTGCAAGATGCTCAAGCCGGAAGAAGAATTCCCCTAGAACAAATGTGGGAGGGAATTGATGCC
GAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7G7VTK1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7G7VTK2 |