Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2901738..2902267 Replicon chromosome
Accession NZ_CP019988
Organism Enterococcus faecium isolate 2014-VREF-63

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag B4W80_RS14750 Protein ID WP_002296560.1
Coordinates 2902001..2902267 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag B4W80_RS14745 Protein ID WP_002296559.1
Coordinates 2901738..2902001 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4W80_RS14730 2899112..2900935 + 1824 WP_002294202.1 APC family permease -
B4W80_RS14735 2901077..2901262 - 186 WP_002296558.1 transcriptional regulator -
B4W80_RS14745 2901738..2902001 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B4W80_RS14750 2902001..2902267 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
B4W80_RS14755 2902468..2902956 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
B4W80_RS14760 2903497..2904168 - 672 WP_002302663.1 ABC transporter permease -
B4W80_RS14765 2904165..2905082 - 918 WP_002302664.1 osmoprotectant ABC transporter substrate-binding protein -
B4W80_RS14770 2905079..2905719 - 641 Protein_2728 ABC transporter permease -
B4W80_RS14775 2905723..2906898 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T73666 WP_002296560.1 NZ_CP019988:2902001-2902267 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T73666 NZ_CP019988:2902001-2902267 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT73666 WP_002296559.1 NZ_CP019988:2901738-2902001 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT73666 NZ_CP019988:2901738-2902001 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References