Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4580079..4580733 Replicon chromosome
Accession NZ_CP019986
Organism Citrobacter werkmanii strain BF-6

Toxin (Protein)


Gene name cptA Uniprot ID A0A2Z3X2B8
Locus tag B2G73_RS22615 Protein ID WP_038633481.1
Coordinates 4580326..4580733 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag B2G73_RS22610 Protein ID WP_016154349.1
Coordinates 4580079..4580345 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2G73_RS22580 4575282..4576715 - 1434 WP_079226020.1 6-phospho-beta-glucosidase BglA -
B2G73_RS22585 4576836..4577564 - 729 WP_042310878.1 MurR/RpiR family transcriptional regulator -
B2G73_RS22590 4577617..4577949 + 333 WP_079226021.1 N(4)-acetylcytidine aminohydrolase -
B2G73_RS22595 4578091..4578750 + 660 WP_038633489.1 hemolysin III family protein -
B2G73_RS22600 4578842..4579822 - 981 WP_079226022.1 tRNA-modifying protein YgfZ -
B2G73_RS22610 4580079..4580345 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
B2G73_RS22615 4580326..4580733 + 408 WP_038633481.1 protein YgfX Toxin
B2G73_RS22620 4580833..4581354 - 522 WP_038633478.1 flavodoxin FldB -
B2G73_RS22625 4581467..4582363 + 897 WP_038633475.1 site-specific tyrosine recombinase XerD -
B2G73_RS22630 4582387..4583100 + 714 WP_061382414.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B2G73_RS22635 4583106..4584839 + 1734 WP_079226024.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15944.81 Da        Isoelectric Point: 11.2845

>T73663 WP_038633481.1 NZ_CP019986:4580326-4580733 [Citrobacter werkmanii]
VVQWQSDLRVSWRAQWLSLLVHGLVAVFILLMPWPLSYTPLWMVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIVSAPWMVKTGMMLRLRSDTGKRQHLWLAADSMDEAEWRDLRRLMLQQAKQG

Download         Length: 408 bp

>T73663 NZ_CP019986:4580326-4580733 [Citrobacter werkmanii]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCGTGGCGCGCGCAGTGGCTTTCGTTGCTTGTTCATGGGCTGGTCGCGGT
ATTTATTTTATTGATGCCCTGGCCTTTGAGCTACACCCCCTTATGGATGGTTTTGCTCTCTCTGGTGGTGTTCGATAGCG
TACGCAGCCAACGTAGAATTAACGCCTGTCAGGGCGAGATTAGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAG
GAGTGGACTATCGTGAGCGCGCCCTGGATGGTCAAAACAGGCATGATGCTGCGTTTGCGTTCAGATACCGGGAAACGTCA
GCATTTGTGGCTGGCGGCAGACAGTATGGATGAGGCTGAGTGGCGAGACTTACGGCGGTTAATGCTGCAACAGGCGAAGC
AGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT73663 WP_016154349.1 NZ_CP019986:4580079-4580345 [Citrobacter werkmanii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT73663 NZ_CP019986:4580079-4580345 [Citrobacter werkmanii]
ATGGATATTAATAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGTGAGCTGGACATCTCTATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGACGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTCAGTTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3X2B8

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References