73648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-vapB/MazF(toxin)
Location 1523476..1524295 Replicon chromosome
Accession NZ_CP019981
Organism Pediococcus inopinatus strain DSM 20285

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag PI20285_RS07745 Protein ID WP_057774311.1
Coordinates 1523924..1524295 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PI20285_RS07740 Protein ID WP_057774359.1
Coordinates 1523476..1523841 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PI20285_RS07715 1519029..1519991 + 963 WP_057774324.1 L-lactate dehydrogenase -
PI20285_RS07720 1520177..1521568 + 1392 WP_057774322.1 L,D-transpeptidase family protein -
PI20285_RS07725 1521692..1522339 + 648 WP_057774319.1 CBS domain-containing protein -
PI20285_RS07730 1522387..1522896 - 510 WP_057774316.1 QueT transporter family protein -
PI20285_RS07735 1522991..1523479 + 489 WP_057774314.1 GNAT family N-acetyltransferase -
PI20285_RS07740 1523476..1523841 - 366 WP_057774359.1 DUF488 family protein Antitoxin
PI20285_RS07745 1523924..1524295 - 372 WP_057774311.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PI20285_RS07750 1524314..1524574 - 261 WP_057774308.1 hypothetical protein -
PI20285_RS07755 1524649..1525776 - 1128 WP_057774305.1 alanine racemase -
PI20285_RS07760 1525785..1526144 - 360 WP_057774302.1 holo-ACP synthase -
PI20285_RS07765 1526400..1527647 - 1248 WP_062904581.1 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-113)

Antitoxin

Protein of unknown function DUF488

(4-115)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13271.30 Da        Isoelectric Point: 8.5686

>T73648 WP_057774311.1 NZ_CP019981:c1524295-1523924 [Pediococcus inopinatus]
MSEANVKRGDIFYADLSPVVGSEQGGLRPVLIVQNNIGNHYSPTVIVAAITAKIQKPKMPTHVGITAAETGVERNSVILL
EQIRTIDKQRLKDQVGQLTTSKMLEVDAALKVSVGLAENVQHT

Download         Length: 372 bp

>T73648 NZ_CP019981:c1524295-1523924 [Pediococcus inopinatus]
ATGAGTGAAGCCAACGTTAAACGTGGCGACATTTTTTATGCTGACTTGTCTCCTGTAGTTGGGTCTGAACAGGGTGGCTT
GCGCCCTGTTCTAATTGTTCAAAACAATATCGGTAATCACTATAGTCCTACTGTGATTGTGGCAGCTATTACTGCTAAAA
TACAAAAACCAAAAATGCCAACTCATGTTGGAATTACAGCTGCAGAGACAGGCGTTGAACGAAATTCAGTTATTTTGCTG
GAACAGATTCGGACAATTGATAAACAACGGCTTAAGGATCAAGTCGGACAATTGACCACCAGCAAAATGCTAGAGGTAGA
TGCAGCCTTAAAGGTTAGTGTCGGACTAGCCGAAAACGTTCAACATACATAG

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 14302.46 Da        Isoelectric Point: 9.5347

>AT73648 WP_057774359.1 NZ_CP019981:c1523841-1523476 [Pediococcus inopinatus]
MQIKLERIYTKPAYLGGYRVLVDRLWPRGISKVNAQLDWWAKEIGPSTDLRKWFGHDPEKFTEFTKKYVAELNSSEFTRG
FLDKIKEQLKTQDVIFLYGAKDETHNQAIVLKAYIEEKFQV

Download         Length: 366 bp

>AT73648 NZ_CP019981:c1523841-1523476 [Pediococcus inopinatus]
ATGCAAATCAAGTTGGAAAGAATTTATACCAAACCGGCATATTTAGGTGGCTATCGGGTGCTGGTAGATCGGCTGTGGCC
AAGAGGAATTTCTAAAGTTAACGCTCAGTTAGATTGGTGGGCAAAAGAAATAGGACCAAGTACCGACCTGAGGAAATGGT
TCGGACATGATCCCGAAAAGTTTACTGAATTCACAAAAAAATATGTAGCGGAACTCAACAGTTCCGAATTTACTAGGGGA
TTTCTGGATAAGATCAAGGAACAACTGAAAACTCAAGACGTTATTTTTCTTTATGGGGCTAAAGATGAAACGCACAACCA
AGCAATCGTGTTAAAGGCCTACATTGAAGAAAAATTTCAGGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References