Detailed information of TA system TA073641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 249024..249636
• Replicon: chromosome
• Accession: NZ_CP019978
• Organism: Streptococcus agalactiae strain Sag37

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8G2N8L3
• Locus tag: B1H24_RS01480
• Protein ID: WP_000384860.1
• Coordinates: 249024..249359 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: B1H24_RS01485
• Protein ID: WP_000259017.1
• Coordinates: 249349..249636 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B1H24_RS01450	244222..244863	+	642	WP_000591144.1	hypothetical protein	-
B1H24_RS01460	245163..246038	+	876	WP_000421240.1	hypothetical protein	-
B1H24_RS01465	246074..246508	+	435	WP_001220479.1	hypothetical protein	-
B1H24_RS01470	246825..248081	+	1257	WP_000122836.1	plasmid recombination protein	-
B1H24_RS01475	248249..248719	+	471	WP_000130119.1	hypothetical protein	-
B1H24_RS01480	249024..249359	-	336	WP_000384860.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B1H24_RS01485	249349..249636	-	288	WP_000259017.1	hypothetical protein	Antitoxin
B1H24_RS01490	250143..250433	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
B1H24_RS01495	250535..250941	+	407	Protein_231	hypothetical protein	-
B1H24_RS01500	250941..251501	+	561	WP_001865562.1	hypothetical protein	-
B1H24_RS01505	251474..252154	+	681	WP_001865565.1	hypothetical protein	-
B1H24_RS01510	252139..252525	+	387	WP_000259069.1	hypothetical protein	-
B1H24_RS01515	252559..252840	+	282	WP_000052406.1	hypothetical protein	-
B1H24_RS01535	253672..254532	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	241055..249910	8855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13227.87 Da
• Isoelectric Point: 4.5348

>T73641 WP_000384860.1 NZ_CP019978:c249359-249024 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENSVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T73641 NZ_CP019978:c249359-249024 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGCGTTGTCATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT73641 WP_000259017.1 NZ_CP019978:c249636-249349 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT73641 NZ_CP019978:c249636-249349 [Streptococcus agalactiae]
ATGGTTACAGTAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6