Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2513859..2514348 Replicon chromosome
Accession NZ_CP019962
Organism Eubacterium limosum strain ATCC 8486

Toxin (Protein)


Gene name relE Uniprot ID A0A317S0V5
Locus tag B2M23_RS11815 Protein ID WP_038352201.1
Coordinates 2514073..2514348 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A317RXL4
Locus tag B2M23_RS11810 Protein ID WP_038352202.1
Coordinates 2513859..2514080 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2M23_RS21230 2509163..2509315 + 153 WP_167617884.1 hypothetical protein -
B2M23_RS11790 2509454..2509948 + 495 WP_038352206.1 hypothetical protein -
B2M23_RS11795 2509979..2511472 - 1494 WP_038352205.1 glycerol kinase GlpK -
B2M23_RS11800 2511484..2513019 - 1536 WP_038352204.1 amidohydrolase -
B2M23_RS11805 2513024..2513599 - 576 WP_167617886.1 glycerol-3-phosphate responsive antiterminator -
B2M23_RS11810 2513859..2514080 + 222 WP_038352202.1 ribbon-helix-helix protein, CopG family Antitoxin
B2M23_RS11815 2514073..2514348 + 276 WP_038352201.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B2M23_RS11820 2514469..2517840 + 3372 WP_038352200.1 exodeoxyribonuclease V subunit gamma -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-89)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10646.43 Da        Isoelectric Point: 10.1275

>T73624 WP_038352201.1 NZ_CP019962:2514073-2514348 [Eubacterium limosum]
MAEKYHVVLTEKAKKSLKKLDKHTALLITAWLRKNLEGCTDPYQYGKGLTANRSGQWRYRIGDYRLVCEISEQTITILVL
NIGHRKEIYKH

Download         Length: 276 bp

>T73624 NZ_CP019962:2514073-2514348 [Eubacterium limosum]
TTGGCTGAAAAATATCATGTTGTTTTAACTGAAAAAGCAAAAAAGAGTTTAAAAAAACTTGATAAGCATACAGCGCTTTT
GATTACAGCTTGGTTGAGGAAAAATCTTGAGGGCTGCACCGATCCCTATCAGTACGGCAAGGGCCTCACCGCTAACCGCA
GCGGACAATGGCGCTACCGCATCGGCGATTACCGTCTGGTCTGCGAGATTTCCGAGCAGACGATCACGATTCTGGTTTTA
AATATTGGGCACAGAAAAGAAATTTACAAACATTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8523.66 Da        Isoelectric Point: 4.1285

>AT73624 WP_038352202.1 NZ_CP019962:2513859-2514080 [Eubacterium limosum]
MAVSLRLNKEDEALIRSYAEMKNLSVSEAIRQAIMEKIEDEFDLKVYYEAMTEYKENPVTYTLDEVERELGLG

Download         Length: 222 bp

>AT73624 NZ_CP019962:2513859-2514080 [Eubacterium limosum]
ATGGCTGTATCATTAAGATTAAACAAAGAGGATGAAGCGTTGATCCGGAGCTATGCGGAGATGAAAAATCTATCCGTTTC
TGAGGCGATTCGTCAGGCGATCATGGAAAAAATTGAGGATGAGTTCGACTTGAAGGTTTACTATGAGGCCATGACGGAGT
ATAAGGAAAATCCAGTGACTTATACCTTGGATGAAGTAGAAAGAGAGCTGGGACTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A317S0V5

Antitoxin

Source ID Structure
AlphaFold DB A0A317RXL4

References