Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 3300613..3301172 Replicon chromosome
Accession NZ_CP019959
Organism Vibrio owensii strain XSBZ03

Toxin (Protein)


Gene name relE Uniprot ID A0A2K7SRU8
Locus tag A9237_RS15420 Protein ID WP_017035198.1
Coordinates 3300613..3300891 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag A9237_RS15425 Protein ID WP_005398409.1
Coordinates 3300888..3301172 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9237_RS15380 3297220..3297681 + 462 WP_078608550.1 GNAT family N-acetyltransferase -
A9237_RS15385 3297700..3297810 + 111 WP_072609782.1 DUF3265 domain-containing protein -
A9237_RS15390 3297830..3298189 + 360 WP_078608551.1 hypothetical protein -
A9237_RS15395 3298189..3298305 + 117 WP_078608737.1 DUF3265 domain-containing protein -
A9237_RS15400 3298337..3298795 + 459 WP_078608552.1 GNAT family N-acetyltransferase -
A9237_RS15405 3298773..3298913 + 141 WP_078608736.1 DUF3265 domain-containing protein -
A9237_RS15410 3299497..3300456 + 960 WP_078608553.1 DUF2971 domain-containing protein -
A9237_RS15415 3300426..3300584 + 159 WP_078608554.1 DUF3265 domain-containing protein -
A9237_RS15420 3300613..3300891 - 279 WP_017035198.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
A9237_RS15425 3300888..3301172 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A9237_RS15430 3301249..3301377 + 129 WP_078608555.1 DUF3265 domain-containing protein -
A9237_RS15435 3301379..3301930 + 552 WP_078608556.1 GrpB family protein -
A9237_RS15440 3301935..3302051 + 117 WP_080640403.1 DUF3265 domain-containing protein -
A9237_RS15450 3302385..3302495 + 111 WP_078608739.1 DUF3265 domain-containing protein -
A9237_RS15455 3302638..3302748 + 111 WP_078608740.1 DUF3265 domain-containing protein -
A9237_RS15460 3302866..3303318 + 453 WP_033006609.1 hypothetical protein -
A9237_RS15465 3303315..3303803 + 489 WP_078608557.1 hypothetical protein -
A9237_RS15470 3304032..3304496 + 465 WP_078608741.1 hypothetical protein -
A9237_RS15475 3304496..3304990 + 495 WP_078608558.1 hypothetical protein -
A9237_RS15480 3305124..3305615 + 492 Protein_2887 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3258787..3310720 51933
- inside Integron - - 3257030..3303318 46288


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10905.60 Da        Isoelectric Point: 4.3430

>T73603 WP_017035198.1 NZ_CP019959:c3300891-3300613 [Vibrio owensii]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWIEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T73603 NZ_CP019959:c3300891-3300613 [Vibrio owensii]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTCTCTTACTGGATTGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT73603 WP_005398409.1 NZ_CP019959:c3301172-3300888 [Vibrio owensii]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT73603 NZ_CP019959:c3301172-3300888 [Vibrio owensii]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGAGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K7SRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References