Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3520455..3521290 | Replicon | chromosome |
| Accession | NZ_CP019953 | ||
| Organism | Escherichia coli M8 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A085P7I8 |
| Locus tag | B2H83_RS17535 | Protein ID | WP_001562089.1 |
| Coordinates | 3520913..3521290 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A085P7I7 |
| Locus tag | B2H83_RS17530 | Protein ID | WP_001327592.1 |
| Coordinates | 3520455..3520823 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| B2H83_RS17495 | 3517141..3517596 | + | 456 | WP_000581502.1 | hypothetical protein | - |
| B2H83_RS17505 | 3517880..3518698 | + | 819 | WP_001234639.1 | DUF945 domain-containing protein | - |
| B2H83_RS17510 | 3518698..3518943 | + | 246 | WP_073520780.1 | antirestriction protein | - |
| B2H83_RS17515 | 3519037..3519510 | + | 474 | WP_129542005.1 | antirestriction protein | - |
| B2H83_RS17520 | 3519526..3520002 | + | 477 | WP_001186724.1 | RadC family protein | - |
| B2H83_RS17525 | 3520071..3520292 | + | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| B2H83_RS17530 | 3520455..3520823 | + | 369 | WP_001327592.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| B2H83_RS17535 | 3520913..3521290 | + | 378 | WP_001562089.1 | TA system toxin CbtA family protein | Toxin |
| B2H83_RS17540 | 3521287..3521561 | + | 275 | Protein_3366 | malate transporter | - |
| B2H83_RS17545 | 3521533..3521775 | + | 243 | WP_073520782.1 | hypothetical protein | - |
| B2H83_RS17550 | 3521795..3521992 | + | 198 | WP_000445282.1 | DUF957 domain-containing protein | - |
| B2H83_RS17555 | 3522077..3522919 | + | 843 | WP_001519083.1 | DUF4942 domain-containing protein | - |
| B2H83_RS17560 | 3523200..3523736 | - | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| B2H83_RS17565 | 3523738..3524916 | - | 1179 | WP_000094989.1 | type II secretion system protein GspL | - |
| B2H83_RS17570 | 3524913..3525890 | - | 978 | WP_000633239.1 | type II secretion system minor pseudopilin GspK | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 3454989..3587228 | 132239 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14345.29 Da Isoelectric Point: 9.1643
>T73590 WP_001562089.1 NZ_CP019953:3520913-3521290 [Escherichia coli M8]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STSPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKR
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STSPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKR
Download Length: 378 bp
>T73590 NZ_CP019953:3520913-3521290 [Escherichia coli M8]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCATCTCCAGTAACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTAAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTAGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCATCTCCAGTAACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTAAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTAGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13901.65 Da Isoelectric Point: 6.3165
>AT73590 WP_001327592.1 NZ_CP019953:3520455-3520823 [Escherichia coli M8]
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT73590 NZ_CP019953:3520455-3520823 [Escherichia coli M8]
GTGTCAGACACGCACCATGAGACAAATTATCCCGACGACTATAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCATAAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGACTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACGCACCATGAGACAAATTATCCCGACGACTATAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCATAAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGACTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A085P7I8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A085P7I7 |