Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 309278..309994 Replicon chromosome
Accession NZ_CP019952
Organism Pseudomonas parafulva strain PRS09-11288

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag B2J77_RS01325 Protein ID WP_078477835.1
Coordinates 309812..309994 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8I0VNS3
Locus tag B2J77_RS01320 Protein ID WP_058638931.1
Coordinates 309278..309724 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2J77_RS01305 306474..306680 - 207 WP_078477832.1 DUF3079 domain-containing protein -
B2J77_RS01310 307018..307830 + 813 WP_078477833.1 alpha/beta hydrolase -
B2J77_RS01315 307823..308980 + 1158 WP_078477834.1 HAMP domain-containing histidine kinase -
B2J77_RS01320 309278..309724 - 447 WP_058638931.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
B2J77_RS01325 309812..309994 - 183 WP_078477835.1 type II toxin-antitoxin system HicA family toxin Toxin
B2J77_RS01340 311117..311365 - 249 WP_078477836.1 hypothetical protein -
B2J77_RS01345 311965..312255 + 291 WP_058639967.1 DUF3077 domain-containing protein -
B2J77_RS01350 312682..313887 - 1206 WP_078477837.1 methyltransferase -
B2J77_RS01355 314001..314690 - 690 WP_078477838.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6822.85 Da        Isoelectric Point: 11.6882

>T73565 WP_078477835.1 NZ_CP019952:c309994-309812 [Pseudomonas parafulva]
VHSRDIIKRLKDDGWVRVKGTDGSHQQFKHPTRKGRVTVPHPSKDVAIGTLRNIWKQAGL

Download         Length: 183 bp

>T73565 NZ_CP019952:c309994-309812 [Pseudomonas parafulva]
GTGCACAGCCGAGACATCATCAAGCGGCTAAAGGATGACGGTTGGGTCAGAGTTAAAGGGACTGATGGGAGCCACCAGCA
GTTCAAGCATCCAACCAGGAAGGGACGGGTTACGGTTCCTCATCCGAGTAAAGATGTGGCAATCGGGACGCTTCGAAACA
TCTGGAAGCAAGCCGGTCTCTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16397.38 Da        Isoelectric Point: 4.3924

>AT73565 WP_058638931.1 NZ_CP019952:c309724-309278 [Pseudomonas parafulva]
MKYPVVLHKDEDSDYGVTVPDVPGCFSAGETIDEALSEVQLALEMHFEGLVEDGEPLPQPQNIELHRKDPAYADGIWAFV
EFDVTPYYGKSVRFNASLPEGLLKRIDDRVKEDSSYASRSGFLAAAALHELAKNLNEGIDALKTRKTV

Download         Length: 447 bp

>AT73565 NZ_CP019952:c309724-309278 [Pseudomonas parafulva]
ATGAAATACCCAGTTGTTTTGCACAAAGATGAAGATTCCGATTACGGAGTGACAGTTCCAGACGTACCGGGCTGCTTCTC
TGCTGGCGAAACGATCGATGAAGCATTGAGCGAAGTCCAACTTGCGTTAGAGATGCACTTTGAAGGTTTGGTAGAAGATG
GAGAGCCTCTGCCGCAACCTCAAAACATCGAACTTCATAGGAAGGACCCGGCTTATGCCGATGGCATCTGGGCTTTCGTA
GAATTCGACGTCACCCCCTACTATGGGAAGTCGGTTCGCTTTAACGCGTCTTTACCAGAAGGTCTCCTCAAACGCATAGA
TGATCGCGTGAAAGAAGACAGCTCTTATGCGTCCAGATCAGGATTTTTAGCCGCGGCGGCGCTGCACGAGCTGGCGAAAA
ACTTAAACGAAGGCATAGACGCTTTAAAAACCAGAAAGACAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References